Frequency of Hyperlipidemia in Type 2 Diabetes Mellitus Patients with Microalbuminuria

Authors

  • Maeda Jabeen Department of Medicine, Combined Military Hospital Jhelum/National University of Medical Sciences (NUMS) Pakistan
  • Sehrish Kanwal Department of Medicine, Combined Military Hospital Jhelum/National University of Medical Sciences (NUMS) Pakistan
  • Jamal Waris Department of Medicine, Combined Military Hospital Jhelum/National University of Medical Sciences (NUMS) Pakistan
  • Asad Sufain Azeem Department of Medicine, Combined Military Hospital Jhelum/National University of Medical Sciences (NUMS) Pakistan
  • Kahlid Ibrahim Ahktar Department of Medicine, Combined Military Hospital Jhelum/National University of Medical Sciences (NUMS) Pakistan
  • Amna Nasar Department of Medicine, Combined Military Hospital Jhelum/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i2.7580

Keywords:

Diabetes Mellitus, Hyperlipidemia, Microalbuminuria

Abstract

Objective: To evaluate the frequency of hyperlipidemia in type 2 diabetes mellitus (DM) patients with microalbuminuria attending a tertiary care hospital.

Study Design: Cross-sectional study

Place and Duration of Study: Combined Military Hospital, Jhelum Pakistan, from Jan 2020 to Feb 2021.

Methodology: All patients aged 30 years or above with type 2 DM mellitus presented with or without microalbuminuria were consecutively enrolled. Hyperlipidemia was defined based on the presence of an elevated lipid profile. This information, along with baseline and other predicting factors, was noted.

Results: Of 236 patients, hyperlipidemia was observed in 107(45.3%) patients with type 2 DM having microalbuminuria. The odds of hyperlipidemia were 53% less likely among patients aged ≤59 years than that of patients aged>59 years [aOR: 0.47, 95% CI: 0.27-0.85], 47% less likely among patients with ≤7 years of diabetes duration as compared to >7 years of duration of diabetes [aOR: 0.53, 95% CI: 0.29-0.96], and 75% less likely among patients with ≤140 mm Hg SBP as compared to the patients with >140 mm Hg SBP [aOR: 0.25, 95% CI: 0.14-0.46].

Conclusion: In the current study, hyperlipidemia was observed to be considerably higher in patients with type 2 DM having microalbuminuria. Moreover, elderly patients, longer diabetes duration, and elevated blood pressure are some of the risk factors reported in our patients.

Downloads

Download data is not yet available.

References

Roden M, Shulman GI. The integrative biology of type 2 diabetes.

Nature 2019; 576(7785): 51-60.

https://doi.org/10.1038/s41586-019-1797-8

Bommer C, Sagalova V, Heesemann E, Manne-Goehlr J, Atun R,

Bärnighausen T, et al. Global Economic Burden of Diabetes in

Adults: Projections From 2015 to 2030. Diabetes Care 2018; 41(5):

-970.

https://doi.org/10.2337/dc17-1962

Reddy V, Inamdar P. A comparative study of foot infections in

diabetic and non-diabetic patients with reference to

etiopathogenesis, clinical features and outcome. Int Surg J 2020;

(5): 1496-1502. https://doi.org/10.18203/2349-2902.isj20201858

Niemann U, Spiliopoulou M, Malanowski J, Kellersmann J,

Szczepanski T, Klose S, et al. Plantar temperatures in stance

position: A comparative study with healthy volunteers and

diabetes patients diagnosed with sensoric neuropathy.

EBioMedicine 2020; 54: 102712.

https://doi.org/10.1016/j.ebiom.2020.102712

Animaw W, Seyoum Y. Increasing prevalence of diabetes mellitus

in a developing country and its related factors. PLoS One 2017;

(11): e0187670. https://doi.org/10.1371/journal.pone.0187670

Aamir AH, Ul-Haq Z, Mahar SA, Qureshi FM, Ahmad I, Jawa A,

et al. Diabetes Prevalence Survey of Pakistan (DPS-PAK):

prevalence of type 2 diabetes mellitus and prediabetes using

HbA1c: a population-based survey from Pakistan. BMJ Open

; 9(2): e025300.

https://doi.org/10.1136/bmjopen-2018-025300

Adnan M, Aasim M. Prevalence of type 2 diabetes mellitus in

adult population of Pakistan: A meta-analysis of prospective

cross-sectional surveys. Ann Glob Health 2020; 86(1): 7.

https://doi.org/10.5334/aogh.2679

Ijaz M, Ali I, Hussain A. Diabetes mellitus in Pakistan: the past,

present, and future. Int J Diabetes Dev Ctries. 2020; 40(1): 153-154.

https://doi.org/10.1007/s13410-019-00754-x

IDF Diabetes Atlas. 9th Edition. International Diabetes

Federation; 2019.

Russo G, Piscitelli P, Giandalia A, Viazzi F, Pontremoli R, Fioretto

P, et al. Atherogenic dyslipidemia and diabetic nephropathy. J

Nephrol 2020; 33(5): 1001-1008.

https://doi.org/10.1007/s40620-020-00739-8

Tolonen N, Forsblom C, Thorn L, Wadén J, Rosengård-Bärlund

M, Saraheimo M, et al. Relationship between lipid profiles and

kidney function in patients with type 1 diabetes. Diabetologia

; 51(1): 12-20. https://doi.org/10.1007/s00125-007-0858-y

Palazhy S, Viswanathan V. Lipid abnormalities in type 2 diabetes

mellitus patients with overt nephropathy. Diabetes Metabol J

; 41(2): 128-134.

https://doi.org/10.4093%2Fdmj.2017.41.2.128

Naha S, Naha K, Pandit VR, Balasubramanian R. Association of

microalbuminuria with ischemic heart disease in non-diabetic

Asian-Indians: A case control study. Avicenna J Med 2015; 5(1): 6-

https://doi.org/10.4103%2F2231-0770.148501

Wang SH, Wang L, Zhou Y, Guo YJ, Yuan Y, Li FF, et al.

Prevalence and control of dyslipidaemia among diabetic patients

with microalbuminuria in a Chinese hospital. Diabetes Vasc Dis

Res 2013; 10(2): 169-178.

https://doi.org/10.1177/1479164112454756

Ahmad T, Ulhaq I, Mawani M, Islam N. Microalbuminuria in

Type-2 Diabetes Mellitus; the tip of iceberg of diabetic

complications. Pak J Med Sci 2017; 33(3): 519-523.

https://doi.org/10.12669%2Fpjms.333.12537

Tomlinson B, Patil NG, Fok M, Lam CWK. Managing

dyslipidemia in patients with Type 2 diabetes. Expert Opin

Pharmacother 2021; 22(16): 2221-2234.

https://doi.org/10.1080/14656566.2021.1912734

Lazarte J, Hegele RA. Dyslipidemia management in adults with

diabetes. Can J Diabetes 2020; 44(1): 53-60.

https://doi.org/10.1016/j.jcjd.2019.07.003

Zhang L, Qiao Q, Tuomilehto J, Hammar N, Janus ED, Söderberg

S, et al. Blood lipid levels in relation to glucose status in seven

populations of Asian origin without a prior history of diabetes:

the DECODA study. Diabetes Metab Res Rev 2009; 25(6): 549-557.

https://doi.org/10.1002/dmrr.994

Byrne P, Cullinan J, Smith SM. Statins for primary prevention of

cardiovascular disease. BMJ 2019; 367: 15674.

https://doi.org/10.1136/bmj.l5674

Aslan I, Kucuksayan E, Aslan M. Effect of insulin analog

initiation therapy on LDL/HDL subfraction profile and HDL

associated enzymes in type 2 diabetic patients. Lipids Health Dis

; 12: 54. https://doi.org/10.1186/1476-511X-12-54

Downloads

Published

29-04-2024

Issue

Section

Original Articles

How to Cite

1.
Maeda Jabeen, Sehrish Kanwal, Jamal Waris, Asad Sufain Azeem, Kahlid Ibrahim Ahktar, Amna Nasar. Frequency of Hyperlipidemia in Type 2 Diabetes Mellitus Patients with Microalbuminuria. Pak Armed Forces Med J [Internet]. 2024 Apr. 29 [cited 2024 Dec. 26];74(2):455-8. Available from: https://pafmj.org/PAFMJ/article/view/7580