Clinical and Echocardiographic Features of Rheumatic Heart Disease at First Presentation at a Tertiary Care Setup
DOI:
https://doi.org/10.51253/pafmj.v74i2.7386Keywords:
Echocardiography, Mitral regurgitation, Rheumatic fever, Rheumatic heart diseaseAbstract
Objective: To find out the mode of presentation and severity of cardiac involvement in children presented with established rheumatic heart diseases (RHD) at first presentation at a tertiary care setup.
Study Design: Cross-sectional study.
Place and Duration of the Study: Department of Pediatric Cardiology, National Institute of Cardiovascular Disease, Karachi Pakistan, from Jul 2020 to Jun 2021.
Methodology: One hundred seven children of genders aged 3 to 18 with a confirmed diagnosis of RHD were included. Demographic features, chief presenting complaints, possible reasons for late presentation, and echocardiographic findings were noted.
Results: In 107 patients with RHD, 63(58.9%) were male. The sensation of the rapid pounding of heartbeat (palpitation) was observed among 72(67.3%) children, while a similar number of cases, 72(67.3%), presented with breathlessness. There were 33(30.8%) children who were diagnosed for the first time with RHD. The most common reason for late diagnosis was socioeconomic factors in children (18, 26.1%). Primary prophylaxis for acute rheumatic fever (ARF)/RHD was noted to be given in 11(10.3%) patients. Mitral regurgitation was the most common echocardiographic finding in 103(96.3%), followed by aortic regurgitation in 99(92.5%).
Conclusion: The majority of children with RHD are diagnosed late, which exposes them to an increased risk of undiagnosed valvular disorders. Palpitation, orthopnea and breathlessness were RHD most frequent presenting clinical features. Mitral regurgitation and aortic regurgitation were the most common echocardiographic findings.
Downloads
References
Joseph N, Madi D, Kumar GS, Nelliyanil M, Saralaya V, Rai S. et
al. Clinical spectrum of rheumatic Fever and rheumatic heart
disease: a 10 year experience in an urban area of South India. N
Am J Med Sci 2013; 5(11): 647-652.
https://doi.org/10.4103/1947-2714.122307.
Animasahun BA, Madise Wobo AD, Itiola AY, Adekunle MO,
Kusimo OY, Thomas FB. Et al. The burden of rheumatic heart
disease among children in Lagos: how are we fairing? Pan Afr
Med J 2018; 29: 150.
https://doi.org/10.11604/pamj.2018.29.150.12603.
Guilherme L, Ramasawmy R, Kalil J. Rheumatic fever and
rheumatic heart disease: genetics and pathogenesis. Scand J
Immunol 2007; 66(2-3): 199-207.
https://doi.org/10.1111/j.1365-3083.2007.01974.
Carapetis JR. Rheumatic heart disease in developing countries. N
Engl J Med 2007; 357(5): 439-441.
https://doi.org/10.1056/NEJMp078039.
Riaz A, Hanif MI, Khan IH, Hanif A, Mughal S, Anwer A. et al.
Quality of life in patients with rheumatic heart disease. J Pak Med
Assoc 2018; 68(3): 370-375.
Akhtar N, Sadiq M, Chagani H, Hafeez A, Rizvi FH, Mehboob M.
et al. Guidelines for prevention of Rheumatic fever and rheumatic
heart disease. Pak J Cardiol 2004; 15: 136–148.
Rizvi SF, Khan MA, Kundi A, Marsh DR, Samad A, Pasha O. et al.
Status of rheumatic heart disease in rural Pakistan. Heart 2004;
(4): 394-399. https://doi.org/10.1136/hrt.2003.025981.
Ilyas M, Peracha MA, Ahmed R, Khan N, Ali N, Janjua M. et al.
Prevalence and pattern of rheumatic heart disease in the Frontier
Province of Pakistan. J Pak Med Assoc 1979; 29(8): 165–168.
Okello E, Ndagire E, Muhamed B, Sarnacki R, Murali M, Pulle J,
et al. Incidence of acute rheumatic fever in northern and western
Uganda: a prospective, population-based study. Lancet Glob
Health 2021; 9(10): e1423-e1430.
https://doi.org/10.1016/S2214-109X(21)00288-6.
Beaton A, Carapetis J. The 2015 revision of the Jones criteria for
the diagnosis of acute rheumatic fever: implications for practice in
low-income and middle-income countries. Heart Asia 2015; 7(2):
-11. https://doi.org/10.1136/heartasia-2015-010648.
Cannon J, Roberts K, Milne C, Carapetis JR. Rheumatic Heart
Disease Severity, Progression and Outcomes: A Multi-State
Model. J Am Heart Assoc 2017; 6(3): e003498.
https://doi.org/10.1161/JAHA.116.003498.
Nair B, Viswanathan S, Koshy AG, Gupta PN, Nair N, Thakkar A.
et al. Rheumatic Heart Disease in Kerala: A Vanishing Entity? An
Echo Doppler Study in 5-15-Years-Old School Children. Int J
Rheumatol 2015; 2015: 930790.
https://doi.org/10.1155/2015/930790.
Lilyasari O, Prakoso R, Kurniawati Y, Roebiono PS, Rahajoe AU,
Sakidjan I, et al. Clinical Profile and Management of Rheumatic
Heart Disease in Children and Young Adults at a Tertiary
Cardiac Center in Indonesia. Front Surg 2020; 7: 47.
https://doi.org/10.3389/fsurg.2020.00047.
Boyarchuk O, Hariyan T, Kovalchuk T. Clinical features or
rheumatic heart disease in children and adults in Western
Ukraine. Bangladesh J Med Sci 2019; 18(1): 87-93.
https://doi.org/10.3329/bjms.v18i1.39556.
Shrestha NR, Kalesan B, Karki P, Sherpa K, Basnet A, Urban P, et
al. Rheumatic heart disease: pilot study for a population-based
evaluation of prevalence and cardiovascular outcomes among
schoolchildren in Nepal. BMJ Open 2012; 2(5): e001616.
. Muhamed B, Shaboodien G, Engel ME. Genetic variants in
rheumatic fever and rheumatic heart disease. Am J Med Genet C
Semin Med Genet 2020; 184(1): 159-177.
https://doi.org/10.1002/ajmg.c.31773.
Gray LA, D'Antoine HA, Tong SYC, McKinnon M, Bessarab D,
Brown N, et al. Genome-wide analysis of genetic risk factors for
Rheumatic Heart Disease in Aboriginal Australians provides
support for pathogenic molecular mimicry. J Infect Dis 2017;
(11): 1460-1470. https://doi.org/10.1093/infdis/jix497.
Antunes MJ. The global burden of rheumatic heart disease:
Population-related differences (it is not all the same!). Braz J
Cardiovasc Surg 2020; 35(6): 958-963.
https://doi.org/10.21470%2F1678-9741-2020-0514.
Dougherty S, Beaton A, Nascimento BR, Zühlke LJ, Khorsandi M,
Wilson N. Prevention and control of rheumatic heart disease:
Overcoming core challenges in resource-poor environments. Ann
Pediatr Cardiol 2018; 11(1): 68-78.