Vitamin D and Calcium Pharmaceutical Supplements: All we Need  to Know to Choose the Right One

Authors

  • Hafsa Majid Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi Pakistan
  • Nawazish Zehra Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi Pakistan
  • Ablooj Khan Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi Pakistan
  • Lena Jafri Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi Pakistan
  • Aysha Habib Khan Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i3.7361

Keywords:

Calcium, Composition, Deficiency, Supplements, Vitamin D, Toxicity.

Abstract

Calcium and Vitamin D deficiency is highly prevalent in Pakistan. Both micronutrients have a significant role in human growth and development. Supplementation becomes essential when the available natural sources like food and sunlight, cannot replenish the deficiencies. Nevertheless, it is critical that while prescribing Calcium or Vitamin D supplements, physicians should know the composition and specific application of each supplement. This review explores the different types of Calcium and Vitamin D pharmaceutical supplements available in the market their composition, indication and contraindications. Data of Calcium and Vitamin D supplements has been collected by Pakistani drug sites databases, including ‘Drug Infosys (www.druginfosys.com)’, ‘Dawaee.pk’, ‘Sehat.com.pk’ and ‘Medicine Net’ by pharmacists and orthopaedists. The commonly prescribed supplements are Cholecalciferol (Vitamin D) and Calcium Carbonate (Calcium). Over time, an increase in market share of Vitamin D and Calcium supplementations is due to their over-the-counter availability, increased physicians' prescriptions, and self-prescribed use by the population. There is a need to develop national guidelines and policies to safeguard the population's health at large.   

Downloads

Download data is not yet available.

References

Christakos S, Dhawan P, Porta A, Mady LJ, Seth T. Vitamin D and intestinal Calcium absorption. Mol Cell Endocrinol 2011; 347 (1-2): 25-29.

https://doi.org/10.1016/j.mce.2011.05.038

Smith H. Calcium supplementation: nutrition. S Afr Pharm Assist 2012; 12(1): 38-42.

Bruyère O, Cavalier E, Souberbielle JC, Bischoff-Ferrari HA, Beaudart C, Buckinx F et al. Effects of Vitamin D in the elderly population: current status and perspectives. Arch Public Health 2014; 72 (1): 1-10.

https://doi.org/10.1186/2049-3258-72-32.

Aspell N, Laird E, Healy M, Lawlor B, O'Sullivan M. Vitamin D deficiency is associated with impaired muscle strength and physical performance in community-dwelling Older Adults: Findings From The English Longitudinal Study Of Ageing. Clin Interv Aging 2019; 14: 1751.

https://doi.org/10.2147/CIA.S222143

Hollis BW, Wagner CL. Vitamin D supplementation during pregnancy: Improvements in birth outcomes and complications through direct genomic alteration. Mol. Cell. Endocrinol 2017; 453: 113-130. https://doi.org/10.1016/j.mce.2017.01.039

Mundy GR, Guise TA. Hormonal control of Calcium homeostasis. Clin. Chem 1999; 45(8): 1347-1352.

https://doi.org/10.1093/clinchem/45.8.1347

Fleet JC. The role of Vitamin D in the endocrinology controlling Calcium homeostasis. Mol. Cell. Endocrinol 2017; 453: 36-45.

https://doi.org/10.1016/j.mce.2017.04.008

Iqbal R, Khan AH. Possible causes of Vitamin D deficiency (VDD) in Pakistani population residing in Pakistan. J Pak Med Assoc 2010; 60(1): 1-2.

Khan AH, Majid H, Iqbal R. Shifting of Vitamin D deficiency to hyperVitaminosis and toxicity. J Coll Physicians Surg Pak 2014; 24(7): 536–536.

Vitamin D Deficiency. Pakistan National Nutrition Survey 2018. Nutrition Wing, Ministry of National Health Services, Regulation and Coordination, Government of Pakistan, 2019.

Khan AH, Iqbal R, Naureen G, Dar FJ, Ahmed FN. Prevalence of Vitamin D deficiency and its correlates: Results of a community-based study conducted in Karachi, Pakistan. Arch Osteoporos 2012; 7(1–2): 275–282.

https://doi.org/10.1007/s11657-012-0108-x

Van Riet-Nales DA, Schobben AFAM, Vromans H, Egberts TCG, Rademaker CMA. Safe and effective pharmacotherapy in infants and preschool children: Importance of formulation aspects. Arch Dis Child 2016; 101(7): 662–669.

https://doi.org/10.1136/archdischild-2015-308227

Kalra S,. Vitamin D deficiency: Diagnosis and patient centred management. J Pak Med Assoc 2015; 65(5): 569-573.

Chun RF, Shieh A, Gottlieb C, Yacoubian V, Wang J, Hewison M, et al. Vitamin D binding protein and the biological activity of Vitamin D. Front Endocrinol 2019; 10: 718.

https://doi.org/10.3389/fendo.2019.00718

Schacht E, Richy F, Reginster JY. The therapeutic effects of alfacalcidol on bone strength, muscle metabolism and prevention of falls and fractures. J Musculoskelet Neuronal Interact 2005; 5(3): 273–284.

Fortification Assessment Coverage Toolkit (FACT) survey in Pakistan, 2017 by Global Alliance for Improved Nutrition (GAIN), USAID and Oxford Policy Management (OPM), 2017.

Brandi ML. Indications on the use of Vitamin D and Vitamin D metabolites in clinical phenotypes. Clin Cases Miner Bone Metab 2010; 7(3): 243–250.

IOF. Calcium Calculator|International Osteoporosis Foundation 2017. https://www.iofbonehealth.org/Calcium-calculator2017

Khan MN, Masood MQ, Siddiqui MA, Naz S, Islam N. Vitamin-D Toxicity And Other Non-Malignant Causes Of Hypercalcemia: A Retrospective Study At A Tertiary Care Hospital In Pakistan. J Ayub Med Coll Abbottabad 2017; 29(3): 436-440.

Downloads

Published

28-06-2024

Issue

Section

Review Articles

How to Cite

1.
Majid H, Zehra N, Khan A, Jafri L, Khan AH. Vitamin D and Calcium Pharmaceutical Supplements: All we Need  to Know to Choose the Right One. Pak Armed Forces Med J [Internet]. 2024 Jun. 28 [cited 2024 Jul. 17];74(3):884-9. Available from: https://pafmj.org/PAFMJ/article/view/7361