Diagnostic Accuracy of Mammography for Breast Cancer Diagnosis, Taking Histopathology asStandard Investigation

Authors

  • Sidra Latif Department of Surgery, Jinnah Postgraduate Medical Centre Karachi Pakistan
  • Sughra Perveen Department of Surgery, Jinnah Postgraduate Medical Centre Karachi Pakistan
  • Mazhar Iqbal Department of Surgery, Jinnah Postgraduate Medical Centre Karachi Pakistan
  • Tanweer Ahmed Department of Surgery, Jinnah Postgraduate Medical Centre Karachi Pakistan
  • Kulsoom Moula Bux Department of Surgery, Jinnah Postgraduate Medical Centre Karachi Pakistan
  • Jehangir Ali Soomro Department of Surgery, Jinnah Postgraduate Medical Centre Karachi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74iSUPPL-2.7157

Keywords:

Breast Cancer, Histopathology, Mammography, Radiology.

Abstract

Objective: To find out the exact accuracy of diagnosis of Mammography for females presented with breast lump.
Study Design: A cross-sectional observational study
Place and Duration of Study: Ward 3, Jinnah Postgraduate Medical Center, Karachi Pakistan, from Sep 2021 to Dec 2021.
Methodology: Total 210 female patients above 35 years of age, with breast lump presented in outpatient department of Jinnah 
postgraduate Medical Centre enrolled in this study. Out of 210 patients, 80 patients were provisionally diagnosed as benign 
breast lump i-e BIRADS I, II and III, and 130 as malignant i-e BIRADS IV, V, and VI were included on the basis of 
Mammography done from Radiology department. Trucut biopsy of the breast lump of more than 2cm and excision biopsy of 
the lump less than 2cm was done. Final diagnosis of histopathological report compared with provisional diagnosis. Results 
were noted on Performa and analyzed.
Results: A total of 210 patients were enrolled in the study on the basis of Mammography. Out of 210 patients, 130(61.9%) 
patients were considered as malignant and 80(38.1%) patients as benign lumps. Diagnostic accuracy of Mammography was 
96.19%, taking histopathology as standard investigation. The sensitivity, specificity, positive predictive value, and negative 
predictive value, were 98.41%, 92.86%, 95.38%, and 97.50%, respectively.
Conclusion: Mammography proved significantly diagnostic for carcinoma of breast.

Downloads

Download data is not yet available.

References

Manzoor S, Anwer M, Soomro S, Kumar D. Presentation,

diagnosis and management of locally advanced breast cancer: Is it

different in low/middle income countries? Pak J Med Sci 2019;

(6): 1554-1557.

https://doi.org/10.12669/pjms.35.6.165

Chalasani P, Kiluk V J. Breast cancer clinical presentation.

Medscape drugs and dis [Internet]. Available from:

https://emedicine.medscape.com/article/1947145-clinical

Provencher L, Hogue JC, Desbiens C, Poirier B, Poirier E,

Boudreau D, et al. Is clinical breast examination important for

breast cancer detection? Curr Oncol 2016; 23(4): e332-e339.

https://doi.org/10.3747/co.23.2881

Luo W-q, Huang Q-x, Huang X-w, Hu H-t, Zeng F-q, Wang W.

Predicting Breast Cancer in Breast Imaging Reporting and Data

System (BI-RADS) Ultrasound Category 4 or 5 Lesions: A

Nomogram Combining Radiomics and BI-RADS. Sci Rep 2019;

(1): 11921. https://doi.org/10.1038/s41598-019-48488-4

Yang L, Wang S, Zhang L, Sheng C, Song F, Wang P, et al.

Performance of ultrasonography screening for breast cancer: a

systematic review and meta-analysis. BMC Cancer 2020; 20(1):

https://doi.org/10.1186/s12885-020-06992-1

Triantafillidou ES. Enhancing the Critical Role of Core Needle

Biopsy in Breast Cancer. Hell Cheirourgike 2020; 92(2): 76-84.

https://doi.org/10.1007/s13126-020-0550-y

Ogbuanya AU-O, Anyanwu SN, Iyare EF, Nwigwe CG. The Role

of Fine Needle Aspiration Cytology in Triple Assessment of

Patients with Malignant Breast Lumps. Niger J Surg 2020; 26(1):

-41. https://doi.org/10.4103/njs.NJS_50_19

Qureshi MA, Khan S, Sharafat S, Quraishy MS. Common Cancers

in Karachi, Pakistan: 2010-2019 Cancer Data from the Dow Cancer

Registry. Pak J Med Sci 2020; 36(7): 1572.

https://doi.org/10.12669/pjms.36.7.3056

Pervin M, Nath H, Bahar M, Alam A, Bhowmik J. Study on

Clinical Presentation of Breast Carcinoma of 50 Cases.

Chattagram Maa-O-Shishu Hosp Med College J 2014; 13(2): 8-11.

https://doi.org/10.3329/cmoshmcj.v13i2.21048

Takalkar1 UV, Asegaonkar SB, Kulkarni U, Saraf M, Advani S.

Clinicopathological Profile of Breast Cancer Patients at a Tertiary

Care Hospital in Marathwada Region of Western India. Asian Pac

J Cancer Prev 2016; 17(4): 2195-2198.

https://doi.org/10.7314/apjcp.2016.17.4.2195

Huang Y, Kang M, Li H, Li JY, Zhang JY, Liu LH, et al. Combined

performance of physical examination, mammography, and

ultrasonography for breast cancer screening among Chinese

women: a follow-up study. Curr Oncol 2012; 19(Suppl 2): eS22-

eS30. https://doi.org/10.3747/co.19.1137

Zafar A. Clinical breast examination; the diagnostic accuracy in

palpable breast lumps. Professional Med J. 2014; 21(6): 1147-1152.

https://pesquisa.bvsalud.org/portal/resource/pt/emr-162191

Bichoo RA, Yadav SK, Mishra A, Lal P, Chand G, Agarwal G, et

al. Fungating Breast Cancer: Experience in Low- and MiddleIncome Country. Indian J Surg Oncol 2020; 11(2): 281-286.

https://doi.org/10.1007/s13193-020-01040-7

Brown AL, Phillips J, Slanetz PJ, Fein-Zachary V, Venkataraman

S, Dialani V, et al. Clinical value of mammography in the

evaluation of palpable breast lumps in women 30 years old and

older. Am J Roentgenol 2017; 209(4): 935-942.

Devolli-Disha E, Manxhuka-Kërliu S, Ymeri H, Kutllovci A.

Comparative accuracy of mammography and ultrasound in

women with breast symptoms according to age and breast

density. Bosn J Basic Med Sci 2009; 9(2): 131-136.

https://doi.org/10.17305/bjbms.2009.2832

Mammography for Breast Cancer

Pak Armed Forces Med J 2024; 74(Suppl-2): S131

Haghighi F, Naseh G, Mohammadifard M, Abdollahi N.

Comparison of mammography and ultrasonography findings

with pathology results in patients with breast cancer in Birjand,

Iran Electron Physician 2017; 9(10): 5494-5498.

https://doi.org/10.19082/5494

Ying X, Lin Y, Xia X, Hu B, Zhu Z, He P. A comparison of

mammography and ultrasound in women with breast disease: a

receiver operating characteristic analysis. J Breast 2012; 18(2): 130-

https://doi.org/10.1111/j.1524-4741.2011.01219.x

Masciadri N, Ferranti C. Benign breast lesions: Ultrasound. J

Ultrasound 2011; 14(2): 55-65.

https://doi.org/10.1016/j.jus.2011.03.002

Alawi A, Hasan M, Harraz MM, Kamr WH, Alsolami S,

Mowalwei H, et al. Breast lesions in women under 25 years:

radiologic-pathologic correlation. Egypt J Radiol Nucl Med 2020;

(1): 96. https://doi.org/10.1186/s43055-020-00209-y

Kocaay AF, Celik SU, Sevim Y, Ozyazici S, Cetinkaya OA, Alic

KB. The role of fine needle aspiration cytology and core biopsy in

the diagnosis of palpable breast masses. Niger Med J 2016; 57(2):

-80. https://doi.org/10.4103/0300-1652.18207

Downloads

Published

18-11-2024

Issue

Section

Original Articles

How to Cite

1.
Sidra Latif, Perveen S, Iqbal M, Ahmed T, Bux KM, Soomro JA. Diagnostic Accuracy of Mammography for Breast Cancer Diagnosis, Taking Histopathology asStandard Investigation. Pak Armed Forces Med J [Internet]. 2024 Nov. 18 [cited 2025 Jan. 19];74(SUPPL-2):S127-S131. Available from: https://pafmj.org/PAFMJ/article/view/7157