Association of Various Factors with Thrombocytopenia in Neonates, Secondary to Maternal Pregnancy-Induced Hypertension
DOI:
https://doi.org/10.51253/pafmj.v74i1.7115Keywords:
Infant, Newborn, Hypertension, Pregnancy-Induced, Blood platelets, Platelet count, Infant, Low birth weight, Very low birth weight, PregnancyAbstract
Objective: To assess the presence of Thrombocytopenia among the neonates born to mothers having pregnancy-induced
hypertension and associated socio-demographic factors.
Study Design: Cross-sectional study.
Place and Duration of Study: Pak Emirates Military Hospital, Rawalpindi Pakistan, from Apr to Jun 2021.
Methodology: This study was conducted on neonates who were born to mothers who were diagnosed and managed with
pregnancy-induced hypertension. Thrombocytopenia was defined as a platelet count of <150,000/μl and was performed after 24 hours of birth till seven days of age. Gender of the neonate, Birth weight, gestational age and mode of delivery were the factors studied with Thrombocytopenia in the study population.
Results: A total of 300 neonates born to mothers with pregnancy-induced hypertension were included in the study. The mean age of the mothers included in the study was 34.16±2.443 years, while the mean age of the neonates was 3.66±2.33 years. Of them, 90(30%) had the presence of Thrombocytopenia, while 210(70%) had a normal platelet count. 160(53.3%) were male neonates, while 140(46.7%) were female. Low birth weight of neonates and gestational age <37 weeks had a statistically significant relationship (p-value<0.05) with the presence of Thrombocytopenia in neonates born to mothers with pregnancyinduced hypertension.
Conclusion: Thrombocytopenia was a common finding among neonates born to mothers who suffered from pregnancyinduced hypertension. Neonates born at less than 37 weeks and those with low birth weight were more at risk of developing Thrombocytopenia as compared to neonates who were born at term with normal weight.
Downloads
References
Ndwiga C, Odwe G, Pooja S, Ogutu O, Osoti A, Warren CE.
Clinical presentation and outcomes of pre-eclampsia and
eclampsia at a national hospital, Kenya: A retrospective cohort
study. PLoS One 2020; 15(6): e0233323.
https://doi.org/10.1371/journal.pone.0233323.
Braunthal S, Brateanu A. Hypertension in pregnancy:
Pathophysiology and treatment. SAGE Open Med 2019; 7:
https://doi.org/10.1177/2050312119843700.
Davenport P, Sola-Visner M. Hemostatic Challenges in Neonates.
Front Pediatr 2021; 9: 627715.
https://doi.org/10.3389/fped.2021.627715.
Resch E, Hinkas O, Urlesberger B, Resch B. Neonatal
thrombocytopenia-causes and outcomes following platelet
transfusions. Eur J Pediatr 2018; 177(7): 1045-1052.
https://doi.org/10.1007/s00431-018-3153-7.
Thrombocytopenia in Neonates with PIH
Pak Armed Forces Med J 2024; 74(1): 20
Saber AM, Aziz SP, Almasry AZE, Mahmoud RA. Risk factors
for severity of thrombocytopenia in full term infants: a single
center study. Ital J Pediatr 2021; 47(1): 7.
https://doi.org/10.1186/s13052-021-00965-1.
Sillers L, Van Slambrouck C, Lapping-Carr G. Neonatal
Thrombocytopenia: Etiology and Diagnosis. Pediatr Ann 2015;
(7): e175-e180. https://doi.org/10.3928/00904481-20150710-11.
Eslami Z, Lookzadeh MH, Noorishadkam M, Hashemi A,
Ghilian R, Pirdehghan A. Thrombocytopenia and associated
factors in neonates admitted to NICU during Years 2010_2011.
Iran J Ped Hematol Oncol 2013; 3(1): 205-215.
Kalagiri RR, Choudhury S, Carder T, Govande V, Beeram MR,
Uddin MN, et al. Neonatal Thrombocytopenia as a consequence
of maternal preeclampsia. AJP Rep 2016; 6(1): e42-e47.
https://doi.org/10.1055/s-0035-1565923.
Cakir SC, Dorum BA, Koksal N, Ozkan H. The effects of
maternal preeclampsia on inflammatory cytokines and clinical
outcomes in premature infants. Pak J Med Sci 2020; 36(2): 26-31.
https://doi.org/10.12669/pjms.36.2.1316.
Baig JAR, Jamal MM. Maternal and perinatal outcome in
pregnancy induced hypertensive mothers in Combined Military
Hospital, Sialkot. Pak Armed Forces Med J 2020; 70 (4): 896-901
Tesfa E, Nibret E, Gizaw ST, Zenebe Y, Mekonnen Z, Assefa S, et
al. Prevalence and determinants of hypertensive disorders of
pregnancy in Ethiopia: A systematic review and meta-analysis.
PLoS One 2020; 15(9): e0239048.
https://doi.org/10.1371/journal.pone.0239048.
Duhig K, Vandermolen B, Shennan A. Recent advances in the
diagnosis and management of pre-eclampsia. F1000Res 2018;
(1): 242. https://doi.org/10.12688/f1000research.12249.1.
Wiedmeier SE, Henry E, Sola-Visner MC, Christensen RD.
Platelet reference ranges for neonates, defined using data from
over 47,000 patients in a multihospital healthcare system. J
Perinatol 2009; 29(2): 130-136.
https://doi.org/10.1038/jp.2008.141.
Un Nisa S, Shaikh AA, Kumar R. Maternal and Fetal Outcomes
of Pregnancy-related Hypertensive Disorders in a Tertiary Care
Hospital in Sukkur, Pakistan. Cureus 2019; 11(8): e5507.
https://doi.org/10.7759/cureus.5507.
Agarwal K, Narayan S, Kumari S, Logani KB, Agarwal AK.
Pregnancy induced hypertension: changes in coagulation profile
of newborns. Indian J Pathol Microbiol 1995; 38(3): 281-285.
Bhat YR, Cherian CS. Neonatal thrombocytopenia associated
with maternal pregnancy induced hypertension. Indian J Pediatr
; 75(6): 571-573. https://doi.org/10.1007/s12098-008-0110-x.
Bayoumi MAA, Ali AAH, Hamad SG, Ali AAM, Elmalik EE,
Elkalaf MMIR, et al. Effect of maternal preeclampsia on
hematological profile of newborns in qatar. Biomed Res Int 2020;
: 7953289. https://doi.org/10.1155/2020/7953289.
Mouna K, Doddagowda SM, Junjegowda K, Krishnamurthy L.
Changes in Haematological Parameters in Newborns Born to
Preeclamptic Mothers - A Case Control Study in a Rural
Hospital. J Clin Diagn Res 2017; 11(7): EC26-EC29.