Diagnostic Sensitivity and Specificity of Platelet Indices in Sepsis

Aamna Latif; Lubna Zaffar; Sarah Fatimah; Hina Zaib; Maria Khan; Rabia Latif

doi:10.51253/pafmj.v73i5.7044

Authors

Aamna Latif Department of Haematology, Fauji Foundation Hospital, Rawalpindi Pakistan
Lubna Zaffar Department of Haematology, Foundation University Medical College, Rawalpindi Pakistan
Sarah Fatimah Department of Haematology, Combined Military Hospital Hyderabad/ National University of Medical Sciences (NUMS) Pakistan
Hina Zaib Department of Haematology, Ali Medical Centre, Islamabad Pakistan
Maria Khan Department of Haematology, Armed forces institute of Transfusion/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Rabia Latif Department of Physiology, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

DOI:

https://doi.org/10.51253/pafmj.v73i5.7044

Keywords:

Mean platelet volume (MPV), Mean platelet volume/platelet ratio (MPV/PLT ratio), Platelet count (PLT), Receiver operating characteristic (ROC) analysis, Sepsis

Abstract

Objective: to determine the diagnostic sensitivity and specificity of platelet indices [platelet count (PLT), mean platelet volume (MPV), MPV/PLT ratio] in sepsis.

Study Design: Comparative cross-sectional study.

Place and Duration of Study: Fauji Foundation Hospital, Rawalpindi Pakistan, from Jun to Dec 2019.

Methodology: Adult patients (18-70 years old) with clinically diagnosed Sepsis (n=150) and their age-matched controls (n=150) were recruited. Platelet indices were measured, and blood culture samples were sent to the microbiology lab. Septic patients were compared to the control group. Receiver operating characteristic (ROC) curves were generated for diagnostic sensitivity and specificity of platelet indices.

Results: Mean platelet volume and MPV/PLT ratios were significantly raised in sepsis, culture-positive sepsis and culturenegative sepsis compared to the control group. In ROC analysis, MPV had 67.3% sensitivity and 65% specificity, whereas the MPV/PLT ratio had 64.7 % sensitivity and 61% specificity to diagnose sepsis. Higher sensitivity (78%) and specificity (70%) were obtained in Culture positive cases for MPV as compared to sensitivity (64%) and specificity (59%) seen in Culture negative cases. MPV/PLT ratio showed the same sensitivity (64%) and specificity (61%) in both Culture positive and Culture negative cases.

Conclusion: The study concludes that MPV and MPV/PLT ratios are significantly higher in sepsis, culture-positive sepsis and
culture-negative sepsis than in the control.