Comparison of Intravenous Lignocaine and Intravenous Dexmedetomidine for Attenuation of Hemodynamic Stress Response to Laryngoscopy and Endotracheal Intubation

Sana Tariq; Khan Muhammad Yaqoob; Arooj Shahid; Komail Abid; Muhammad Mughal Ul Haq

doi:10.51253/pafmj.v74i4.7000

Authors

Sana Tariq Department of Anesthesiology, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Khan Muhammad Yaqoob Department of Anesthesiology, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Arooj Shahid Department of Pharmacology, Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Komail Abid Department of Anesthesiology, Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Muhammad Mughal Ul Haq Department of Anesthesiology, Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i4.7000

Keywords:

Dexmedetomidine, Intubation, Laryngoscopy, Lignocaine

Abstract

Objective: To compare the efficacy of Lignocaine and Dexmedetomidine in minimizing the hemodynamic stress response associated with laryngoscopy and endotracheal intubation.

Study Design: quasi-experimental study.

Place and Duration of Study: Department of Anesthesiology, Combined Military Hospital Rawalpindi, Pakistan, from Jul 2020 to Feb 2021.

Methodology: A total of 60 patients, aged 18-55 years were included in this study. They were randomly allocated to one of two groups. Group-L received intravenous Lignocaine, 1.5 mg/kg. Group-D received Dexmedetomidine 1 µg/kg as intravenous infusion 10 minutes before induction. Heart rate and mean arterial pressure were monitored at basal, pre-induction, induction, laryngoscopy and intubation and 1, 3, 5 and 10 minutes afterwards.

Results: Significantly reduced stress response was seen in Group-D as compared to Group-L. A lesser increase in heart rate was observed during intubation as compared to basal level in Group-D (14.14%) while it was 37.66% in Group-L. MAP was also seen to be less increased in Group-D (1.07 %) as compared to Group-L (22.6%).

Conclusion: Dexmedetomidine, when infused at a dose of 1 mcg/kg over 10 min prior to intubation, attenuates the hemodynamic stress response more efficiently, in comparison to 1.5 mg/kg of Lignocaine infusion.

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