Impact of Aqueous Neem Leave Extract on Erythromycin Induced Hepatotoxicity

Authors

  • Nausheen Jamshed Fauji Foundation Hospital Islamabad Pakistan
  • Iffat Raza Karachi Institute of Medical Sciences, Karachi/National University of Medical Sciences (NUMS) Pakistan
  • Aqiba Rasheed Islam Medical and Dental College, Sialkot Pakistan
  • Naureen Jamshed Queen Mary University of London, London, England
  • Lubna Akhtar Fauji Foundation Hospital Islamabad Pakistan
  • Nadia Rashid Fauji Foundation Hospital Islamabad Pakistan

DOI:

https://doi.org/10.51253/pafmj.v72i1.6756

Keywords:

Azadirachtica indica, Erythromycin, Hepatotoxicity

Abstract

Objective: To examine the protective effect of aqueous neem leaves extract against damage induced by erythromycin on liver enzyme alkaline phosphatase.

Study Design: Laboratory-based experimental study.

Place and Duration of Study: Anatomy Department, Baqai Medical University, Karachi Pakistan, from Mar to Jun 2018.

Methodology: Eighty male albino wistar rats were taken and were divided randomly into 4 groups. Group-A served as a control group with no drug given. Group-B animals received the drug erythromycin 100 mg/kg body weight orally through gastric lavage. Group-C animals received erythromycin 100 mg/kg body weight and neem leaves extract in a dose of 500 mg/kg body weight orally through gastric lavage. Group-D received only neem extract at the dose of 500 mg/kg body weight orally. After 14 days, blood samples were collected via cardiac puncture and sent to laboratory for the investigation of alkaline phosphatase enzyme.

Results: The alkaline phosphatase enzyme levels of group-B (Erythromycin treated group) were found to be 176.98 ± 10.53 IU/L. When treated with aqueous neem leaves extract the alkaline phosphatase levels decreased to 150.10 ± 2.28 IU/L seen in group-C. The comparisons of group-B and group-C showed statistically significant (p<0.01), showing protective effect of aqueous neem leaves on hepatocytes.

Conclusion: Aqueous neem extract showed protective effect on erythromycin induced hepatic damage.

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Published

01-03-2022

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Original Articles

How to Cite

1.
Jamshed N, Raza I, Rasheed A, Jamshed N, Akhtar L, Rashid N. Impact of Aqueous Neem Leave Extract on Erythromycin Induced Hepatotoxicity. Pak Armed Forces Med J [Internet]. 2022 Mar. 1 [cited 2024 Nov. 23];72(1):235-39. Available from: https://pafmj.org/PAFMJ/article/view/6756