Factors Associated with Breast Cancer Risk According to Tumor Subtypes: Triple Negative Breast Cancer vs. NON-Triple Negative Breast Cancer Among Women in Karachi, Pakistan

Uzma  Shamsi; Azra Shamsi; Shaeryar Usman

doi:10.51253/pafmj.v75iSUPPL-1.6565

Authors

Uzma Shamsi Department of Community Health, Aga Khan University Hospital Karachi Pakistan
Azra Shamsi Department of Gynecology, Combined Military Hospital Malir /National University of Medical Sciences (NUMS) Pakistan
Shaeryar Usman Department of Medicine, Mether Hospital NewYork

DOI:

https://doi.org/10.51253/pafmj.v75iSUPPL-1.6565

Keywords:

Breast cancer, socioeconomic status, triple negative, vitamin D deficiency

Abstract

Objective: To evaluate risk factors associated with triple negative breast cancer among women in Karachi Pakistan

Study Design: Multicenter hospital-based case control study

Place and Duration of Study: Aga Khan University Hospital and Karachi Institute of Radiation & Nuclear Medicine Karachi, Pakistan from February 2015 to July 2018.

Methodology: There were three hundred and eighty cases of breast cancer patients who had complete molecular profiling and who were compared with 798 controls and in person interviews were conducted.

Results: The multivariable multinomial logistic regression analyses showed that both triple negative breast cancer and non- triple negative breast cancer subtypes were associated with poor socioeconomic status and low Vitamin D concentrations with triple negative breast cancer risk much higher among women of low socioeconomic status (OR=8.76, 95% CI= 2.45, 31.32) and women with vitamin D deficiency (OR=3.11, 95%CI= 1.17. 8.29).

Conclusions: Correction of Vitamin D deficiency in women maybe a possible cost-effective strategy to prevent triple negative breast cancer like aggressive breast cancer. It should be further tested though cohort studies or clinical trials in our population.

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