Frequency of 17p Deletion in Chronic Lymphocytic Leukemia Patients Presenting to Combined Military Hospital Rawalpindi

Authors

  • Atiq-ur- Rehman Department of Oncology, Combined Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Riaz Ahmad Department of Oncology, Combined Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Nadeem Department of Oncology, Combined Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Umair Tufail Department of Oncology, Combined Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Amjad Khan Department of Oncology, Combined Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Fayyaz Hussain Department of Medicine, Ayub Teaching Hospital Abbottabad Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i2.6530

Keywords:

17p deletion, Chronic lymphocytic leukemia, Diagnosis, Mutations

Abstract

Objective: To assess the frequency and factors related to the presence of 17p deletion among patients diagnosed with chronic lymphocytic leukaemia at the Oncology Department of Combined Military Hospital Rawalpindi

Study Design: Cross-sectional study.

Setting And Duration Of Study: Oncology Department, Combined Military Hospital, Rawalpindi Pakistan, Feb 2020 to Mar 2021.

Methodology: Patients with Chronic lymphocytic leukaemia were recruited for the study. The fluorescence in situ hybridization method was used to look for the presence of 17p deletion, using 10% cells as a cut-off value. Demographics, treatment status, and β2-microglobulin levels were correlated with 17p deletion in our study population.

Results: A total of 102 patients diagnosed with Chronic Lymphocytic leukaemia were included in the analysis. The mean age of the patients was 55.82±7.176 years.74(72.5%) were male, while 28(27.5%) patients diagnosed with this condition were female. 17p deletion was present in 16(15.7%) patients, while 86(84.3%) patients were not detected with 17p deletion. Elevatedβ2-microglobulin levels were strongly related to 17p deletion in our target population (p-value-0.005).

Conclusion: 17p deletion was a fairly common finding among patients of chronic lymphocytic leukaemia presenting to our department. Patients with elevated β2-microglobulin levels were more at risk of having this genetic mutation than those with normal β2-microglobulin levels.

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Published

27-04-2024

How to Cite

1.
Rehman A- ur-, Ahmad R, Nadeem M, Umair Tufail, Amjad Khan, Fayyaz Hussain. Frequency of 17p Deletion in Chronic Lymphocytic Leukemia Patients Presenting to Combined Military Hospital Rawalpindi. Pak Armed Forces Med J [Internet]. 2024 Apr. 27 [cited 2024 May 24];74(2):269-72. Available from: https://pafmj.org/PAFMJ/article/view/6530

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