Histopathological Analysis of Gastric Biopsies using Updated Sydney System

Muhammad Zubair; Nabeel Khan Afridi; Muhammad Amir Nawaid; Hassan Tariq; Akhter Ali Bajwa; Naveed Khan

doi:10.51253/pafmj.v72i6.6458

Authors

Muhammad Zubair Najran Armed Forces Hospital, Saudi Arabia
Nabeel Khan Afridi Najran Armed Forces Hospital, Saudi Arabia
Muhammad Amir Nawaid Najran Armed Forces Hospital, Saudi Arabia
Hassan Tariq Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Akhter Ali Bajwa Combined Military Hospital, Thall/National University of Medical Sciences (NUMS) Pakistan
Naveed Khan Combined Military Hospital, Peshawar/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v72i6.6458

Keywords:

Gastritis, Helicobacter Pylori, Non-ulcer dyspepsia

Abstract

Objective: To analyse histopathological findings in gastric biopsies of patients with dyspepsia using an updated Sydney System.

Study Design: Retrospective longitudinal study.

Place and Duration of Study: Histopathology Department, Najran Armed Forces Hospital (NAFH), Saudi Arabia, from Jan 2013 to Mar 2020.

Methodology: A total of 408 cases whose gastric biopsies were included in the study, and their histological features were studied.

Results: Among 408 patients included in the study, 191(46.8%) were males, and 217(53.2%) were females. The mean age was 37.0±15.0 years. A total of 343 patients showed gastritis, which was mild 152(44.3%), moderate 158(46.1%) and severe 33(9.6%), respectively. The activity was observed in 200(49.0%) patients. H.pylori infection was observed in 196(48.0%) patients and intestinal metaplasia in 9(2.2%) patients.

Conclusion: Most of the cases with dyspepsia showed histological evidence of gastritis. However, a significant number of patients had no gastric mucosal abnormality. Therefore, adequate and timely treatment of H.pylori infection can significantly reduce related morbidity.