Effect of Mimosa Himalayana Extract on Potassium Oxonate Induced Hyperuricemia in Rat

Bushra Shaheen; Javaria Fatima; Sheikh Maria Qamar; Tooba Malik; Saba Batool; Saima Naureen

doi:10.51253/pafmj.v74i4.6441

Authors

Bushra Shaheen Department of Pharmacology, Bakhtawar Amin Medical and Dental College, Multan Pakistan
Javaria Fatima Department of Pharmacology, Fatima Jinnah Medical University, Lahore Pakistan
Sheikh Maria Qamar Department of Pharmacology, Rashid Latif Medical College, Lahore Pakistan
Tooba Malik Department of Pharmacology, Services Institute of Medical Sciences, Lahore Pakistan
Saba Batool Department of Pharmacology, CMH Institute of Medical Sciences, Bahawalpur Pakistan
Saima Naureen Department of Pharmacology, Lahore Medical & Dental College, Lahore Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i4.6441

Keywords:

Hyperuricemia, Mimosa himalayana extract, Potassium oxonate, Uric Acid

Abstract

Objective: To determine the hypouricemic effect of Mimosa himalayana extract on potassium oxonate induced hyperuricemia in rats.

Study Design: Laboratory-based Experimental study.

Place and Duration of Study: Pharmacology Department, University of Health Sciences Lahore Pakistan, from Jan 2017 to Dec 2018.

Methodology: Forty-eight healthy male Wistar rats were placed randomly in 6 Groups (n=8). Group-I served as negative control while hyperuricemia was induced in Groups II, III, IV, V and VI with potassium oxonate 250 mg/kg intraperitoneally on day 1^st, 3^rd and 7^th. Group-II served as positive control while Group III received allopurinol 5 mg/kg body weight orally once daily for seven days. Groups IV, V and VI were treated with Mimosa himalayana extract 100, 200 and 400 mg/kg body weight by gavage once daily for 7 days respectively. Oral acute toxicity was observed in eighteen rats for three days with a dose of 1000 and 2000 mg/kg body weight. On day seven, all animals were sacrificed, and blood was collected for serum separation. Serum uric acid was measured with the help of chemistry analyzer.

Results: Mimosa himalayana extract showed no signs of acute toxicity in rats with 1000 mg/kg and 2000 mg/kg oral dose. Hyperuricemia was successfully induced with potassium oxonate. Treatment with allopurinol (5 mg/kg) markedly reduced serum uric acid levels (p<0.05). Mimosa himalayana extract (100mg/kg, 200mg/kg and 400mg/kg) also reduced serum uric acid levels significantly (p<0.05).

Conclusion: Mimosa himalayana extract possesses significant hypouricemic effect.

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