Diagnostic Utility of Beta-Catenin in Poorly Differentiated Colorectal Carcinoma


  • Farukh Mir Muhammad Department of Pathology, Pakistan Navy Ship Shifa, Karachi Pakistan
  • Farhan Akhtar Department of Pathology, Pak Emirates Military Hospital/ National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Nighat Jamal Department of Pathology, Pakistan Navy Ship Shifa, Karachi Pakistan
  • Rabia Ahmed Department of Pathology, Pakistan Navy Ship Shifa, Karachi Pakistan
  • Muhammad Asif Department of Pathology, Armed Forces Institute of Pathology/ National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Fatima Wahan Department of Pathology, Pakistan Navy Ship Shifa, Karachi Pakistan




Beta-catenin, Colorectal carcinoma, Immunohistochemistry


Objective: To determine the diagnostic ability of Beta-catenin in poorly differentiated colorectal carcinomas.

Study Design: Cross-sectional study

Place and Duration of Study: Department of Histopathology PNS Shifa Hospital, Karachi Pakistan from Jun 2019 to Jun 2020

Methodology: After ethical approval from the Institutional Review Board, 60 patients of both gender and all age group,
diagnosed with a case of colorectal carcinoma on biopsy and resection specimens analyzed on histopathology on H & E
staining at PNS SHIFA were included in the study. The resection specimens of CRC included those obtained from
hemicolectomy, abdominoperineal resection and biopsies. Beta-catenin was interpreted using immunohistochemistry as
cytoplasmic and nuclear staining with varying intensity. The scoring method was 0 as negative, 1+ as weakly positive, 2+ as
moderate positive, and 3+ as strongly positive.

Results: Among the 60 patients with resection specimens included from hemicolectomy, abdominoperineal resection and
colorectal biopsies, strong nuclear positive results were observed in 30(50 %) patients, moderate nuclear positivity in 12 (20 %), weak nuclear positivity in 6(10 %) and positive cytoplasmic staining in 12(20 %) patients.

Conclusion: Beta-catenin can be used successfully as a diagnostic utility in poorly differentiated colorectal carcinoma patients.




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How to Cite

Farukh Mir Muhammad, Farhan Akhtar, Nighat Jamal, Rabia Ahmed, Muhammad Asif, & Fatima Wahan. (2023). Diagnostic Utility of Beta-Catenin in Poorly Differentiated Colorectal Carcinoma. Pakistan Armed Forces Medical Journal, 73(6), 1586–1589. https://doi.org/10.51253/pafmj.v73i6.6428



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