Assessment of Tumour Budding in Colorectal Adenocarcinomas

Abstract

Colorectal cancer (CRC) is the third most common malignancy worldwide. According to

Pakistan Annual Cancer Registry Report, it is the second most common cancer an

males and sixth most common cancer amongst females.There are multiple

histopathological factors which have an impact on prognosis and survival in

CRC.Colorectal cancer (CRC) is the third most common malignancy worldwide.

According to Pakistan Annual Cancer Registry Report, it is the second most common

cancer an males and sixth most common cancer amongst females.There are multiple

histopathological factors which have an impact on prognosis and survival in

CRC.The features of prognostic significance include perineural invasion,

lymphovascular invasion, infiltrating tumor borders, poorly defined clusters, Extra mural

venous invasion (EMVI) and tumor budding.The main purpose of our study is to

calculate tumor budding according to the method proposed by ITBCC in pT2 colorectal

carcinomas and study its association with other prognostic indicators