Association Between Peritoneal Carcinomatosis and Histopathologic Type of Cancer
DOI:
https://doi.org/10.51253/pafmj.v75iSUPPL-2.5950Keywords:
Carcinoma, Colorectal Cancer, Gastric Cancer, Histopathology, Metastasis, Ovarian Cancer, Peritoneal CarcinomatosisAbstract
Objective: To evaluate histopathological subtypes and to assess age and gender wise differences in histopathological subtypes among patients with peritoneal carcinomatosis presenting at tertiary care hospital of Karachi, Pakistan.
Study Design: Cross-sectional study.
Place and Duration of Study: Medical Oncology Department, Jinnah Postgraduate Medical Center, Karachi Pakistan, from Apr 2019 to Apr 2020.
Methodology: One forty patients of age less than 70 years of any gender with peritoneal carcinomatosis were enrolled. The data regarding socio-demographic factors was collected on pre-designed questionnaire. Patients were undergone for CT scan and results were used to identify cancer type, stage and histological subtype of tumor.
Results: Of 140 patients, the mean age was 44.94±11.62 years. About 78 patients had ovarian cancer (55.7%), 27 had colorectal cancer (19.3%) and 35 patients had gastric cancer (25%) respectively. Most of the patients had serous histology 36(26%) followed by adenocarcinoma 33(24%). There was statistically significant difference in histological subtypes with respect to gender (p=0.001).
Conclusion: Serous histology is the most common histology among patients with peritoneal carcinomatosis and gender-wise the proportions of histological sub-types varies significantly.
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References
Anwar A, Kasi A. Peritoneal Cancer. [Updated 2020 Nov 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from:
https://www.ncbi.nlm.nih.gov/books/NBK562138/
Goodman MT, Shvetsov YB. Incidence of ovarian, peritoneal, and fallopian tube carcinomas in the United States, 1995-2004. Cancer Epidemiol Biomarkers Prev 2009; 18(1): 132-139.
https://doi.org/10.1158/1055-9965.epi-08-0771
Flanagan M, Solon J, Chang KH, Deady S, Moran B, Cahill R, et al. Peritoneal metastases from extra-abdominal cancer - A population-based study. Eur J Surg Oncol 2018; 44(11): 1811-7.
https://doi.org/10.1016/j.ejso.2018.07.049
Mahmoud BE, Abdelzaher AA, Mohamed AA, Metwally LIA. The role of diffusion-weighted MR imaging in assessment of peritoneal lesions: radiologic-pathologic correlation. Egypt J Radiol Nuclear Med 2020; 51(1): 149.
https://doi.org/10.1186/s43055-020-00271-6
Yun WS, Bae JM. Primary peritoneal serous carcinoma, an extremely rare malignancy: A case report and review of the literature. Oncol Lett 2016; 11(6): 4063-4065.
https://doi.org/10.3892/ol.2016.4525
Coccolini F, Gheza F, Lotti M, Virzì S, Iusco D, Ghermandi C, et al. Peritoneal carcinomatosis. World J Gastroenterol 2013; 19(41): 6979-6994.
https://doi.org/10.3748/wjg.v19.i41.6979
Liu S, Staats P, Lee M, Alexander HR, Burke AP. Diffuse mesothelioma of the peritoneum: correlation between histological and clinical parameters and survival in 73 patients. Pathol 2014; 46(7): 604-609.
https://doi.org/10.1097/pat.0000000000000181
Klos D, Riško J, Loveček M, Skalický P, Svobodová I, Krejčí D, et al. Trends in peritoneal surface malignancies: evidence from a Czech nationwide population-based study. World J Surg Oncol 2019; 17(1): 182.
https://doi.org/10.1186/s12957-019-1731-4
Klos D, Riško J, Stašek M, Loveček M, Hanuliak J, Skalický P, et al. Current status of cytoreductive surgery (CRS) and intraperitoneal hyperthermic chemotherapy (HIPEC) in the multimodal treatment of peritoneal surface malignancies. Cas Lek Cesk 2018; 157(8): 419-428.
Quere P, Facy O, Manfredi S, Jooste V, Faivre J, Lepage C, et al. Epidemiology, Management, and Survival of Peritoneal Carcinomatosis from Colorectal Cancer: A Population-Based Study. Dis Colon Rectum 2015; 58(8): 743-752.
https://doi.org/10.1097/dcr.0000000000000412
Gill RS, Al-Adra DP, Nagendran J, Campbell S, Shi X, Haase E, et al. Treatment of gastric cancer with peritoneal carcinomatosis by cytoreductive surgery and HIPEC: a systematic review of survival, mortality, and morbidity. J Surg Oncol 2011; 104(6): 692-698.
https://doi.org/10.1002/jso.22017
Desai JP, Moustarah F. Peritoneal Metastasis. [Updated 2020 Jun 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from:
https://www.ncbi.nlm.nih.gov/books/NBK541114/
Kok NF, de Hingh IH. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal metastases of colorectal origin. Br J Surg 2017; 104(4): 313-315.
https://doi.org/10.1002/bjs.10422
Spiliotis J, Halkia E, de Bree E. Treatment of peritoneal surface malignancies with hyperthermic intraperitoneal chemotherapy-current perspectives. Curr Oncol 2016; 23(3): e266-e275.
https://doi.org/10.3747/co.23.2831
van 't Sant I, Engbersen MP, Bhairosing PA, Lambregts DMJ, Beets-Tan RGH, van Driel WJ, et al. Diagnostic performance of imaging for the detection of peritoneal metastases: a meta-analysis. Eur Radiol 2020; 30(6): 3101-3112.
https://doi.org/10.1007/s00330-019-06524-x
Dirisamer A, Schima W, Heinisch M, Weber M, Lehner HP, Haller J, et al. Detection of histologically proven peritoneal carcinomatosis with fused 18F-FDG-PET/MDCT. Eur J Radiol 2009; 69(3): 536-541.
https://doi.org/10.1016/j.ejrad.2007.11.032
Rosa Agelica Salcedo-Hernandez L-SL-S, Horacio Lopez-Basave, German Calderillo-Ruiz, Angel Herrera-Gomez. Peritoneal carcinomatosis of primary peritoneal origin: A short review. J Cancerol 2014; 1: 55-61.
Solon JG, O'Neill M, Chang KH, Deady S, Cahill R, Moran B, et al. An 18 year population-based study on site of origin and outcome of patients with peritoneal malignancy in Ireland. Eur J Surg Oncol 2017; 43(10): 1924-1931.
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