Frequency of Positive Findings on MRI of The Patients Diagnosed with Vertebral Metastases on Bone Scintigraphy

Syeda Beenish Zahra; Ayesha Isani Majeed; Joveria Ehsan

doi:10.51253/pafmj.v74iSUPPL-2.5858

Authors

Syeda Beenish Zahra Department of Radiology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
Ayesha Isani Majeed Department of Radiology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
Joveria Ehsan Department of Radiology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74iSUPPL-2.5858

Keywords:

Bone scintigraphy, Magnetic Resonance Imaging, Skeletal metastatic disease

Abstract

Objective: The present study is conducted with the aim to compare the bone scan and MRI findings for detecting spinal metastasis in our local population.

Study design and duration: This cross sectional study was conducted at Radiology Department of Pakistan Institute of medical Sciences, Islamabad from May 2019-May 2020.

Material and Methods: Total 30patients with confirmed diagnosis of cancer who were suspected for spinal metastasis on Tc-99m bone scan and sent for radiologic workup for confirm diagnosis of s pine lesions were enrolled. MRI was performed on 1.5-tesla system using standard protocol. Spine was divided into four regions: cervical, thoracic, lumber and sacral regions. Region-wise bone metastasis were analyzed and compared for bone scan and MRI. Interpretations were considered concordant if both reports showed positive for metastatic lesions, while discordant if readings differ.

Results: 63.3% of the study population were female. Mean age of the enrolled patients was 59.3±14.9 years. All the lesions of cervical region were concordant. Most of the discordance for MRI was noted for lumbar region, where 7 patients were reported as negative who were positive on bone scan. In case of bone scintigraphy, 2 patients were discordant for thoracic region who were positive on MRI.

Conclusion: Very low discordance rate exists among MRI and bone scan. MRI is an effective imaging tool for detection of spinal metastasis with added benefits of no radiation dose to the patient and wider availability as compare to the bone scintigraphy.

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References

Chin H, Kim J. Bone Metastasis: Concise Overview. Fed Pract 2015; 32(2): 24-30.

Zhu M, Liu X, Qu Y, Hu S, Zhang Y, Li W, et al. Bone metastasis pattern of cancer patients with bone metastasis but no visceral metastasis. J Bone Oncol 2019; 15(Jan): 1-5.

Niglas M, Tseng CL, Dea N, Chang E, Lo S, Sahgal A. Spinal Cord Compression. InAbeloff's Clinical Oncology 2020; Jan 1 (pp. 786-793).

Ciftdemir M, Kaya M, Selcuk E, Yalniz E. Tumors of the spine. World J Orthop 2016; 7(2): 109-116.

Isaac A, Dalili D, Dalili D, Weber M. State-of-the-art imaging for diagnosis of metastatic bone disease. Radiologe 2020; 60(3): 1–16.

Heindel W, Gübitz R, Vieth V, Weckesser M, Schober O, Schäfers M. The diagnostic imaging of bone metastases. DtschArztebl Int 2014; 111(44): 741-747.

Papandrianos N, Papageorgiou E, Anagnostis A, Papageorgiou K. Efficient Bone Metastasis Diagnosis in Bone Scintigraphy Using a Fast Convolutional Neural Network Architecture. Diagnostics 2020; 10(8): 1-17.

Agrawal A, Purandare N, Shah S, Rangarajan V. Metastatic mimics on bone scan: "All that glitters is not metastatic". Indian J Nucl Med 2016; 31(3): 185-190.

Ghanem N, Altehoefer C, Kelly T, Lohrmann C, Winterer J, Schafer O, et al. Whole-body MRI in comparison to skeletal scintigraphy in detection of skeletal metastases in patients with solid tumors. In Vivo 2006; 20(1): 173–182.

O'Sullivan GJ, Carty FL, Cronin CG. Imaging of bone metastasis: An update. World J Radiol 2015; 7(8): 202-211.

Sohaib SA, Cook G, Allen SD, Hughes M, Eisen T, Gore M. Comparison of whole-body MRI and bone scintigraphy in the detection of bone metastases in renal cancer. Br J Radiol 2009; 82(980): 632-639.

Hamaoka T, Madewell JE, Podoloff DA, Hortobagyi GN, Ueno NT. Bone imaging in metastatic breast cancer. J ClinOncol 2004; 22(14): 2942–2953.

Houssami N, Costelloe CM. Imaging bone metastases in breast cancer: evidence on comparative test accuracy. Ann Oncol.2012; 23(4): 834–843.

Afrin R, Haque FS, Biswas SK, Hossain S, Roy SK, Jahan M. Role of Whole-Body Tc 99m MDP Bone Scintigraphy for Evaluating Skeletal Metastasis in Patients with Lung Cancer. Bangladesh Med Res Counc Bull 2016; 42(3): 132-136.

Uddandam R, Kovilapu U, Jain NK, Grewal DS, Bhattacharjee S, Maheshwari S. A Comparative Study of MRI and Bone Scan in Early Detection of Vertebral Metastases. J Evid Based Med Healthc 2020; 7(24): 1143–1148.

Hosen MA, Begum N, Hossain M, Ahmed P, Mutsuddy P, Chowdhury SA. Tc-99m MDP Bone Scan Evaluation in Breast Cancer: A Study on 425 Patients. Med Today 2018; 30(2): 49–52.

Gosfield E, Alavi A, Kneeland B. Comparison of Radionuclide Bone Scans and Magnetic Resonance Imaging in Detecting Spinal Metastases. J Nuc Med 1993; 34(12): 2191-2198.

Kattapuram SV, Khurana JS, Scot JA, El-Khoury JY. Negative scintigraphy with positive magnetic resonance imaging in bone metastases. Skeletal Radiol 1990; 19(2): 113–116.

Frank JA, Ling A, Patronas NJ. Detection of malignant bone tumors: MR imaging versus scintigraphy. AJR Am J Roentgenol 1990; 155(5): 1043-1048.

Al-Qurainy R, Collis E. Metastatic spinal cord compression: Diagnosis and management. BMJ 2016; 353(May): 1–7