Occurrence of Vitamin B 12 Deficiency in Patients Presenting with Chronic Inflammatory Demyelinating Polyneuropathy

Hikmatullah .; Asif  Hashmat; Wasim  Alamgir; Muhammad Ali  Yousaf; Hassan  Tariq

doi:10.51253/pafmj.v75i6.5674

Authors

Hikmatullah . Department of Neurology, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Asif Hashmat Department of Neurology, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Wasim Alamgir Department of Neurology, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Muhammad Ali Yousaf Department of Neurology, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Hassan Tariq Department of Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75i6.5674

Keywords:

Chronic Inflammatory Demyelinating Polyneuropathy, Deficiency, Vitamin B12.

Abstract

Objective: To determine the frequency of vitamin B 12 deficiency among the patients presenting with chronic inflammatory demyelinating polyneuropathy.

Study Design: Correlational study.

Place and Duration of Study: Department of neurology, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Apr 2020 to Sep 2020.

Methodology: A total of 240 patients of chronic inflammatory demyelinating polyneuropathy diagnosed by consultant neurologist were included in the study. Vitamin B 12 deficiency was diagnosed on the basis of serum B 12 levels done at chemical pathology department of laboratory of own hospital by standard method. Relationship of age, gender, body mass index and duration of chronic inflammatory demyelinating polyneuropathy was assessed with the presence of iron vitamin B 12 deficiency among the chronic inflammatory demyelinating polyneuropathy patients participating in this study.

Results: Out of 240 chronic inflammatory demyelinating polyneuropathy patients studied in the given time period, 204(85%) had no Vitamin B12 deficiency while 36(15%) had presence of clinically significant B 12 deficiency. 168(70%) patients were male while 72(30%) were female. After applying the binary logistic regression analysis, we found that longer duration chronic inflammatory demyelinating polyneuropathy had a statistically significant association with presence of vitamin B12 deficiency in the target population (p-value<0.001).

Conclusion: This study showed a high frequency of Vitamin B 12 deficiency among the patients presenting with chronic inflammatory demyelinating polyneuropathy in our hospital. Patients with longer duration of chronic inflammatory demyelinating polyneuropathy should be considered at high risk for developing the deficiency cobalamin.

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References

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