Efficacy of Steroid Therapy in Management of Sydenham’s Chorea in Children: A Comparative Prospective Study

Authors

  • Mohsin Ali The Children Hospital and Institute of Child Health, Lahore Pakistan
  • Javeria Raza Alvi The Children Hospital and Institute of Child Health, Lahore Pakistan
  • Zia -ur- Rehman The Children Hospital and Institute of Child Health, Lahore Pakistan
  • Tipu Sultan The Children Hospital and Institute of Child Health, Lahore Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i1.5373

Keywords:

Efficacy, Steroid therapy, Sydenham chorea

Abstract

Objective: To determine the efficacy of steroid therapy in Sydenham’s chorea in children.

Study Design: Comparative prospective study.

Place and Duration of Study: Inpatient and Outpatient Department of Pediatric Neurology, Children Hospital and Institute of Child Health, Lahore Pakistan, from Dec 2019 to May 2020.

Methodology: Sixty-eight children of Sydenham’s chorea were divided in Group A and B. Each Group was treated with Diazepam (0.3mg-1mg/kg/day) and an injection of Benzathine Penicillin. Group-B was given additional oral prednisolone (2mg/kg/day) for four weeks, with tapering in the next two weeks. Epidemiological data, clinical features and laboratory parameters were collected. The Universiade Federal de Minas Gerais Sydenham’s chorea Rating Scale (USCRS) was applied to both groups at the presentation after two weeks and four weeks.

Results: Out of 68 patients, the mean Universidade Federal de Minas Gerais (UFMG) Sydenham's Chorea Rating Scale (USCRS) got progressively better in Group-B (mean score improvement was 25.73±5.56 at two weeks and 41.06±6.89 at four weeks) than in Group-A (mean score improvement was 9.12±3.75 at two weeks and 17.97±3.89 at four weeks) with p-value of <0.05.

Conclusion: Steroid therapy significantly improved patients with Sydenham’s chorea compared to those who did not receive any steroid therapy.
Keywords: Efficacy, Steroid therapy, Sydenham chorea.

Downloads

Download data is not yet available.

Downloads

Published

08-03-2023

Issue

Section

Original Articles

How to Cite

1.
Ali M, Alvi JR, Rehman Z- ur-, Sultan T. Efficacy of Steroid Therapy in Management of Sydenham’s Chorea in Children: A Comparative Prospective Study. Pak Armed Forces Med J [Internet]. 2023 Mar. 8 [cited 2024 Jul. 23];73(1):294-97. Available from: https://pafmj.org/PAFMJ/article/view/5373