Association of Parity with Triple Negative Breast Cancer, A Case Control Study

Abstract

Objective: To find out association between number of children and triple negative breast cancer among females presenting at a tertiary care hospital of Karachi.

Study Design: Case control study.

Place and Duration of Study: Medical Oncology Department, Jinnah postgraduate Medical Centre, Karachi, Pakistan from Aug 2019 to Mar 2020.

Methodology: Total 465 patients of age 17-80 years were included using non-probability consecutive sampling technique. About 150 cases were patients with triple negative breast cancer and 315 controls were breast cancer patients other than triple negative breast cancer. SPSS version 23 was used to analyse data.

Results: The mean age of study sample was estimated as 46.07±11.32 years. Most of the females had grade II (53.3%), stage III (44.9%) and invasive ductal carcinoma (IDC) (94.2%) histological type of tumor. In univariate logistic regression model, triple negative breast cancer was found to be associated with high parity (OR=4.51,95% CI=2-10.15, p<0.10), age at menarche [Mean
11.8yrs.] (OR=1.38,95%CI=1.08-1.78, p<0.10) and age at first birth [Mean 20.61yrs.] (OR=1.17,95% CI=1.10-1.23, p<0.10. In multivariate logistic regression model, predictors such as high parity (OR=4.26,95% CI=1.84-9.83, p<0.05), age at menarche (OR=1.31,95%CI=1.01-1.69, p<0.05) and age at first birth (OR=1.20,95% CI=1.13-1.27, p<0.05) remained significantly associated with triple negative breast cancer.

Conclusion: Study showed that high parity is significantly associated with triple negative breast cancer.