COMPARISON OF MEAN FALL IN POST-OPERATIVE HEMOGLOBIN LEVEL AFTER INTRA-ARTICULAR TRANSAMINE VERSUS INTRAENOUS TRANSAMINE IN TOTAL KNEE ARTHROPLASTY

Abstract

Objective: To compare the mean fall in post-operative hemoglobin level after intra-articular transamine versus intravenous transamine in total knee arthroplasty.

Study Design: Quasi-experimental study.

Place and Duration of Study: Department of Orthopedic Surgery, Combined Military Hospital (CMH) Rawalpindi, from Jan 2018 to Jul 2018.

Methodology: A total of 60 patients having osteoarthritis of knee undergoing total knee replacement were included in the study. In the group A, intra-articular transamine (2 grams) was given after end of operation while in group B intravenous transamine (2 grams) was given. All patients in both groups were followed by the researcher himself and fall in hemoglobin levels were measured after 24 hours post-operatively.

Results: The mean age of patients in group A was 58.27 ± 7.01 years and in group B was 58.13 ± 7.90 years. Out of these 60 patients, 35 (58.33%) were females and 25 (41.67%) were males. Mean fall in post-operative hemoglobin in group A (intra-articular transamine) was 0.42 ± 0.23 g/dl and in group B (intravenous transamine) was 1.11 ± 0.43 g/dl (p-value<0.001).

Conclusion: Mean fall in post-operative hemoglobin level after intra-articular transamine is less as compared to intravenous transamine in total knee arthroplasty. Therefore intra articular route should be preferred for this purpose and screening of blood indices should be performed routinely on those who have been given intravenous transamine.