COMPARISON OF INFLAMMATORY MARKERS AS PREDICTORS OF BLOOD STREAM INFECTIONS IN POSITIVE BLOOD CULTURES OF COVID-19 PATIENTS IN A TERTIARY CARE HOSPITAL

Authors

  • Warda Furqan Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Nadia Tayyab Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Sakhawat Ali Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Irfan Ali Mirza Armed Forces Institute of Pathology/ National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Arshad Naseem Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Hafeez Ud Din Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

Keywords:

Blood cultures, Bloodstream infections, COVID-19, Inflammatory markers, Septicemia

Abstract

Objective: To determine the correlation of positive blood cultures in septicemic COVID-19 patients with significantly raised serum inflammatory markers C-reactive protein, lactate dehydrogenase and lactate levels.

Study Design: Cross-sectional study.

Place and Duration of Study: Department of Microbiology, Pak Emirates Military Hospital (PEMH) Rawalpindi from Apr 2020 to Jun 2020.

Methodology: This study included specimens from 69 adult COVID-19 hospitalized patients with moderate to severe infection. Blood cultures of cases with suspected blood stream infections were processed. Positive blood cultures were compared with markedly raised inflammatory markers.

Results: From a of total 69 blood culture specimen, 36 (52.17%) showed bacterial growth whereas 33 (47.82%) had no bacterial growth. The values of serum C-reactive proteins were in moderate to severe range (≥10mg/l) for 33 (91.66%) out of 36 positive blood cultures. The Lactate dehydrogenase values for 34 (94.44%) out of 36 positive blood cultures were in moderate to severe range (≥300U/L). Serum lactate values for 30 (83.33%) out of 36 patients with positive blood cultures were in moderate to severe range (≥2.21mmol/l). This result was statistically significant.

Conclusion: Serum C-reactive proteins, Lactate dehydrogenase and lactate were markedly high in patients with blood stream infections in patients with COVID-19. These inflammatory markers can be used, not only as early predictors of secondary bacterial infections in COVID-19 patients, but can also help to formulate empirical treatment.

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Published

30-07-2020

Issue

Section

Original Articles

How to Cite

1.
Furqan W, Tayyab N, Ali S, Mirza IA, Naseem A, Din HU. COMPARISON OF INFLAMMATORY MARKERS AS PREDICTORS OF BLOOD STREAM INFECTIONS IN POSITIVE BLOOD CULTURES OF COVID-19 PATIENTS IN A TERTIARY CARE HOSPITAL. Pak Armed Forces Med J [Internet]. 2020 Jul. 30 [cited 2024 Jun. 16];70(1):S206-11. Available from: https://pafmj.org/PAFMJ/article/view/4876