Various Clinicopathological Presentaions of Cholestasis in Infants Presenting to  Tertiary Care Hospital: Presentation of Cholestasis in Infants

Javaid  Iqbal; Shabbir  Hussain; Sana  Khan; Hafiz Abdul  Quddus; Hafiz Muhammad Murtaza; Muhammad Nadeem  Chohan

doi:10.51253/pafmj.v75iSUPPL-1.4776

Authors

Javaid Iqbal Department of Pediatric, Combined Military Hospital Skardu/National University of Medical Sciences (NUMS) Pakistan
Shabbir Hussain Department of Pediatric, Pakistan Navy Station Shifa Hospital, Karachi Pakistan
Sana Khan Department of Psychiatry, Combined Military Hospital Skardu/National University of Medical Sciences (NUMS) Pakistan
Hafiz Abdul Quddus Department of Pediatric, Combined Military Hospital Hyderabad/National University of Medical Sciences (NUMS) Pakistan
Hafiz Muhammad Murtaza Department of Pediatric, Combined Military Hospital Tarbela/National University of Medical Sciences (NUMS) Pakistan
Muhammad Nadeem Chohan Department of Pediatric, Bilawal Medical College for Boys LUMHS Jamshoro, Karachi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75iSUPPL-1.4776

Keywords:

Idiopathic neonatal hepatitis, Jaundice, neonatal cholestasis.

Abstract

Objective: To determine various Clinico-pathological presentations of cholestasis in infants presenting to Tertiary Care Hospital.

Study Design: Cross-sectional study.

Place and Duration of Study: Department of Pediatric Medicine, Pakistan Navy Station Shifa Hospital, Karachi Pakistan, from Jan 2022 to Jun 2022.

Methodology: A total of 95 infants with persistent jaundice aged 2 weeks to 12 months of either gender were included. Jaundice case secondary to hemolysis and serious illness were excluded. After taking informed written consent from all children’s parents, clinical presentations i.e. Jaundice, clay-coloured stools, pale stools, hepatomegaly and splenomegaly of cholestasis were noted. Essential labs and radiological investigations were also done at the clinico-pathological Laboratory of our institute.

Results: Mean age of the infants was 4.85±2.48 months. Out of the 95 infants, 61(64.21%) were male and 34(35.79%) were females with a male to female ratio of 1.8:1. Jaundice was present in 95(100%), hepatomegaly 78(82.11%), Acholic stools 74(77.89%), and splenomegaly in 66(69.47%) patients. The common causes of cholestasis were idiopathic neonatal hepatitis in 54(56.84%), biliary atresia in 25(26.32%) and Progressive Familial Intrahepatic Cholestasis in 26(27.37%) patients.

Conclusion: This study has shown that the common clinical feature of cholestasis in infants is jaundice followed by hepatomegaly, acholic stools and splenomegaly. The common cause was idiopathic neonatal hepatitis followed by biliary atresia and progressive familial intrahepatic cholestasis.

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