Role of Salbutamol in The Management of Transient Tachypnea of the Newborn: A Comparative Prospective Study

Waqas Ahmed; Ali Mujtaba Tahir; Fahim Ahmed Subhani; Zeeshan Ahmed; Amina Sohail; Hafsa Javed

doi:10.51253/pafmj.v72i5.4746

Authors

Waqas Ahmed Combined Military Hospital Dera Ismial Khan/National University of Medical Science (NUMS) Rawalpindi Pakistan
Ali Mujtaba Tahir Combined Military Hospital Zhob/ National University of Medical Science (NUMS) Rawalpindi Pakistan
Fahim Ahmed Subhani Islamic International Medical College Riphah Pakistan
Zeeshan Ahmed Pak Emirates Military Hospital/National University of Medical Science (NUMS) Rawalpindi Pakistan
Amina Sohail Combined Military Hospital/National University of Medical Science (NUMS) Rawalpindi Pakistan
Hafsa Javed Bahria University Islamabad Pakistan

DOI:

https://doi.org/10.51253/pafmj.v72i5.4746

Keywords:

Nebulization, Normal saline, Respiratory rate, Salbutamol, Transient tachypnea of the newborn

Abstract

Objective: To compare the outcome of Salbutamol nebulization with normal saline (placebo) in transient tachypnea of the newborn.

Study Design: Comparative prospective study.

Place and Duration of Study: Department of Neonatal Medicine, Military Hospital Rawalpindi, from Jan 2017 to Mar 2018.

Methodology: Sixty term neonates with respiratory rate >60 breaths/min and transient tachypnea of newborn score of ≥4 were enrolled. They were randomly allocated to two equal groups. Group-1 received Salbutamol nebulization (0.15 mg/kg) while Group-2 received normal Saline (placebo) nebulization.

Results: The mean gestational age was 38.31±1.28 weeks, while the average birth weight was 2.97±0.27 kg. The mean change in transient tachypnea of newborn score with Salbutamol nebulization was 5.63±1.22, while 0.63±1.54 with normal Saline nebulization. Likewise, the mean change in respiratory rate with Salbutamol was 9.80±2.05, while -3.73±2.57 with normal saline.

Conclusion: This study demonstrated nebulized Salbutamol as an effective tool in reversing transient tachypnea of newborns with decreasing respiratory rate compared to normal saline nebulization (placebo).