Risk Factors of Colorectal Cancer Other than Genetic Factors at Jinnah Post Graduate Medical Center

Muhammad Hayat Hayat; Ghulam Haider; Raja Rahool; Saima Zahoor; Shakeel Akbar; Perwasha Kerio

doi:10.51253/pafmj.v74iSUPPL-2.4699

Authors

Muhammad Hayat Hayat Department of Oncology, Jinnah Postgraduate Medical Center, Karachi Pakistan
Ghulam Haider Department of Oncology, Jinnah Postgraduate Medical Center, Karachi Pakistan
Raja Rahool Department of Oncology, Jinnah Postgraduate Medical Center, Karachi Pakistan
Saima Zahoor Department of Oncology, Jinnah Postgraduate Medical Center, Karachi Pakistan
Shakeel Akbar Department of General Surgery, Bolan Medical College, Quetta Pakistan
Perwasha Kerio Department of Oncology, Jinnah Postgraduate Medical Center, Karachi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74iSUPPL-2.4699

Keywords:

Colorectal carcinoma, Dietary habits, Genetic risk factors, Obesity, Physically inactive

Abstract

Objective: To determine the association of different risk factors other than genetic factors in patients having colorectal carcinoma.

Study Design: Case control study.

Place and Duration of Study: Medical Oncology Department, Jinnah Postgraduate Medical Center, Karachi Pakistan, from Jan 2019 to Jan 2020.

Methodology: A total of 200 patients of age more than 10 years of either gender were included in the study. Hundred were cases of newly diagnosed colorectal cancer and 100 were healthy controls. The data regarding socio-demographics and risk factors other than genetic risk factors was collected through pre-designed questionnaire.

Results: The mean age of the cases was 42.76±15.02 & the controls were 39.42±14.03 years. After adjusting odds in multivariate analysis, physically inactive (OR=0.40; 95% CI: 0.16-0.98, p<0.05), low fruits and vegetable intake (OR=0.42; 95% CI: 0.22-0.82, p<0.05), processed meat intake (OR=2.00; 95% CI: 1.01-3.96, p<0.05) and fats intake (OR=5.12; 95% CI: 2.68-9.76, p<0.05) remained positively associated with colorectal carcinoma.

Conclusion: Higher risk of developing colorectal carcinoma is associated with obesity, low fruits and vegetables intake, high red meat consumption, processed meat consumption, fats intake, physical inactivity and working during night. The initiative for screening would be helpful in determining the colorectal carcinoma at an early stage. Early diagnosis will increase the survival rate and help increasing long term prognosis of the colorectal carcinoma.

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References

Sarwar MR, Saqib A. Cancer prevalence, incidence and mortality rates in Pakistan in 2012. Cogent Medicine. 2017; 4(1): 1288773.

Siegel R, Naishadham D, Jemal A. Global cancer statistics. CA Cancer J Clin 2013; 63(1): 11-30.

Howlader N, Noone A, Krapcho M, Noone A, Neyman N, Aminou R, et al. SEER cancer statistics review, 1975–2009 (vintage 2009 populations); 2012.

Roselló S, Simón S, Cervantes A. Programmed colorectal cancer screening decreases incidence and mortality. Trans Gastroenterol Hepatol 2019; 4.

Lowery JT, Ahnen DJ, Schroy III PC, Hampel H, Baxter N, Boland CR, et al. Understanding the contribution of family history to colorectal cancer risk and its clinical implications: a state‐of‐the‐science review. Cancer 2016; 122(17): 2633-2645.

Weigl K, Chang-Claude J, Knebel P, Hsu L, Hoffmeister M, Brenner H. Strongly enhanced colorectal cancer risk stratification by combining family history and genetic risk score. Clin Epidemiol 2018; 10: 143.

Jeon J, Du M, Schoen RE, Hoffmeister M, Newcomb PA, Berndt SI, et al. Determining risk of colorectal cancer and starting age of screening based on lifestyle, environmental, and genetic factors. Gastroenterology 2018; 154(8): 2152-2164. e19.

Frezza EE, Wachtel MS, Chiriva-Internati M. Influence of obesity on the risk of developing colon cancer. Gut 2006; 55(2): 285-91.

Jass JR. What's new in hereditary colorectal cancer? Arch Pathol Lab Med 2005; 129(11): 1380-1384.

Oskar A, Meydani S, Russell R. Yogurt and gut function. Am J Clin Nutr 2004; 80(2): 2452-2456.

Ferrari P, Jenab M, Norat T, Moskal A, Slimani N, Olsen A, et al. Lifetime and baseline alcohol intake and risk of colon and rectal cancers in the European prospective investigation into cancer and nutrition (EPIC). Int J Cancer 2007; 121(9): 2065-2072.

Nashar RM, Almurshed KS. Colorectal cancer: a case control study of dietary factors, king faisal specialist hospital and researh center, riyadh, saudi arabia. J Family Community Med 2008; 15(2): 57-64.

Kim S-E, Paik HY, Yoon H, Lee JE, Kim N, Sung M-K. Sex-and gender-specific disparities in colorectal cancer risk. World journal of gastroenterology: WJG 2015; 21(17): 5167.

White A, Ironmonger L, Steele RJ, Ormiston-Smith N, Crawford C, Seims A. A review of sex-related differences in colorectal cancer incidence, screening uptake, routes to diagnosis, cancer stage and survival in the UK. BMC Cancer 2018; 18(1): 1-11.

Rossi M, Jahanzaib Anwar M, Usman A, Keshavarzian A, Bishehsari F. Colorectal cancer and alcohol consumption—populations to molecules. Cancers 2018; 10(2): 38.

Cai S, Li Y, Ding Y, Chen K, Jin M. Alcohol drinking and the risk of colorectal cancer death: a meta-analysis. Eur J Cancer Prev 2014; 23(6): 532-539.

Castelló A, Amiano P, de Larrea NF, Martín V, Alonso MH, Castaño-Vinyals G, et al. Low adherence to the western and high adherence to the mediterranean dietary patterns could prevent colorectal cancer. Eur J Nutr 2019; 58(4): 1495-505.

Bardou M, Barkun AN, Martel M. Obesity and colorectal cancer. Gut 2013; 62(6): 933-947.

Ma Y, Yang Y, Wang F, Zhang P, Shi C, Zou Y, et al. Obesity and risk of colorectal cancer: a systematic review of prospective studies. PLoS One 2013; 8(1): e53916.

Zhang Q, Wang Y, Hu H, Huang R, Xie L, Liu E, et al. Impact of socioeconomic status on survival of colorectal cancer patients. Oncotarget 2017; 8(62): 106-121.

Doubeni CA, Laiyemo AO, Major JM, Schootman M, Lian M, Park Y, et al. Socioeconomic status and the risk of colorectal cancer: an analysis of more than a half million adults in the National Institutes of Health‐AARP Diet and Health Study. Cancer 2012; 118(14): 3636-3644.