Comparison of Analgesic effect of Dexmeditomidine and Paracetamol as Adjuvant with Lignocaine Hydrochloride for Intravenous Regional Anesthesia

Abstract

Objective: To compare and evaluate the analgesic effect of Dexmeditomidine and Paracetamol as adjuvant with lignocaine
hydrochloride following upper limb surgeries.

Study Design: Quasi-experimental study

Place and Duration of Study: Combined Military Hospital, Rawalpindi, Allied Hospital, Faisalabad, Fauji Foundation
Hospital, Rawalpindi Pakistan

Methodology: Sixty ASA physical status I and II patients undergoing upper limb surgery were included in this study. Patients were divided into three groups (n=20) in each group. Regional anesthesia was achieved with 3mg/kg of Lignocaine
hydrochloride(L) (02%) in Group A (n=20). Group B received 3 mg/kg of Lignocaine hydrochloride plus Dexmedetomidine
(D/L) 0.5 μg/kg. Group C (n=20) received 3 mg/kg of lignocaine hydrochloride plus 300 mg of paracetamol (P/L). Onset and
recovery time of Sensory and motor blocks and post-operative pain using visual analogue score was evaluated.

Results: Group B showed significantly less sensory block onset time and motor block onset time as compared with Group A
and Group C. Similarly, sensory block recovery time and motor block recovery time were significantly more in Group B
compared to other groups. visual analogue score was significantly less in Group B in comparison with Group A and C. First
postoperative analgesic request time was significantly longer in the Group B than in Group C.

Conclusion: It was concluded that Dexmedetomidine/Lignocaine hydrochloride provides better analgesia compared to
paracetamol/Lignocaine hydrochloride in intravenous regional anesthesia.