Association of Abnormal Coagulation Tests in Dengue Fever with Clinical Outcomes of The Patients

Zareen Irshad; Nazish Jaffar; Talat Zehra; Faiza Zeeshan; Sunila Tashfeen; Asma Sheikh

doi:10.51253/pafmj.v72i1.4255

Authors

Zareen Irshad Jinnah Sindh Medical University, Karachi Pakistan
Nazish Jaffar Jinnah Sindh Medical University, Karachi Pakistan
Talat Zehra Jinnah Sindh Medical University, Karachi Pakistan
Faiza Zeeshan Jinnah Sindh Medical University, Karachi Pakistan
Sunila Tashfeen Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Asma Sheikh Jinnah Sindh Medical University, Karachi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v72i1.4255

Keywords:

Activated partial thromboplastin time, Dengue, Fibrin degradation products, Prothrombin time

Abstract

Objective: To assess the coagulation test abnormalities (prothrombin time, activated partial thromboplastin time and fibrin degradation products) in dengue fever patients and its impact on clinical outcomes of the patient.

Study Design: Cross-sectional study.

Place and Duration of Study: Hematology Department, Pakistan Naval Ship Shifa Hospital, Karachi Pakistan, from Aug 2016 to Feb 2017.

Methodology: A total of 135, serologically proven positive dengue-infected IgM cases, based on enzyme-linked immunesorbent assay, were included in the study. Prothrombin time, activated partial thromboplastin time, and fibrin degradation products levels were measured on STA Compact Max® (STAGO) and SysmexCA-1500. Clinical Outcomes of the patient were noted.

Results: At the time of admission, elevated prothrombin time was observed in 8(5.6%) cases and remained high at the time of discharge (p-value 0.008). Elevated activated partial thromboplastin time was observed in 57 (42.2%) cases at admission whereas, at discharge, it was observed in 56 (41.5%) cases. Increased level (>5) of fibrin degradation products was seen in 30 (22.2%) cases while at the time of discharge increased level of fibrin degradation products was observed in 25 (18.5%) cases (pvalue 0.007). Out of 135 patients, mortality was observed in two cases and the remaining 133 (98.52%) survived and were discharged.

Conclusion: In conclusion, prothrombin time, activated partial thromboplastin time, and fibrin degradation products can be labeled as early predictors of disease severity and their derangements are associated with clinical outcome in dengue infection.