TO ASCERTAIN THE EEFICACY, COST EFFECTIVENESS OF STREPTOINASE AS INTRALUMINAL THROMBOLYTIC FOR OCLUDED TUNELED CATHETERS IN DIALYSIS PATIENTS OF A TERTIARY CARE HOSPITAL - A SINGLE CENTER EXPERIENCE

Authors

  • Wahaj . Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Batool Butt Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Nadeem Azam Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Khalid Mahmood Raja Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

Keywords:

Dialysis, Occluded tunneled catheters, Streptokinase, Thrombolytic agent

Abstract

Objective: To ascertain the efficacy, cost effectiveness and safety of streptokinase as intraluminal thrombolytic for occluded tunneled catheters in dialysis patients of a tertiary care hospital.

Study Design: Prospective quasi-experimental study.

Place and Duration of Study: Department of Nephrology, Pak Emirates Military Hospital Rawalpindi, from Aug 2018 to Jan 2019.

Methodology: The sample population comprised of 66 patients with occluded tunneled HD catheters who received either streptokinase in a dose of 250,000 unit or 375,000 units. Primary endpoint was the proportion of patients with occluded catheters achieving post-thrombolytic blood flow of ≥300 mL/min which persists for about 30min of hemodialysis. Safety endpoints included the adverse complications like bleeding or any serious allergic reaction.

Results: Out of 60 patients, 30 patients were treated with streptokinase in a dose of 375,000 units and 30 patients with 250,000 units of streptokinase. Hypertension and diabetes were the main causes of end-stage renal disease (50% vs 40%, p=0.08 and 33% vs 33%, p=0.38, respectively) jugular vein as main vascular access (54.8% vs 62.5%, p=0.57). Primary success was achieved in 60% in the first group and 42% in the second group, p=0.012. Patency was not achieved after the second dose in 10% in group-1 and 6.6% in the second group (p=0.31).

Conclusion: Streptokinase, although its efficacy as intraluminal thrombolytic agents is shrouded in disputation but still can be used as a robust and economical thrombolytic agent for occluded HD catheters in our country.

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Published

29-02-2020

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Section

Original Articles

How to Cite

1.
. W, Butt B, Azam N, Raja KM. TO ASCERTAIN THE EEFICACY, COST EFFECTIVENESS OF STREPTOINASE AS INTRALUMINAL THROMBOLYTIC FOR OCLUDED TUNELED CATHETERS IN DIALYSIS PATIENTS OF A TERTIARY CARE HOSPITAL - A SINGLE CENTER EXPERIENCE. Pak Armed Forces Med J [Internet]. 2020 Feb. 29 [cited 2024 Jul. 23];70(1):174-9. Available from: https://pafmj.org/PAFMJ/article/view/3958