FREQUENCY AND PATTERN OF DYSLIPIDEMIA IN CHILDREN WITH END STAGE RENAL DISEASE

Abstract

Objective: To determine the frequency and pattern of dyslipidemia in pediatric patients with end stage renal disease presenting in a tertiary care hospital.

Study Design: Cross-sectional, observational study.

Place and Duration of Study: The Children's hospital and the Institute of Child Health Lahore, from Sep 2016 to Nov 2017.

Material and Methods: Children aged 5-15 years, of either gender and diagnosed with end stage renal disease were selected for the study. All the patients were undergoing renal replacement therapy in the form of hemodialysis and/or continuous ambulatory peritoneal dialysis. The serum levels of total cholesterol, triglycerides, high density lipoprotein, low density lipoprotein and very low density lipoprotein were measured.

Results: There were 138 patients in the study with mean age 11.24 ± 2.37 years and male to female ratio 2.5:1. The mean ± SD values of total serum cholesterol, triglycerides, and low density lipoprotein were found to be 174.0 ± 54.1, 241.2 ± 142.4 and 95.2 ± 49.0 mg/dl respectively. The frequency of abnormally high levels of total serum cholesterol, triglycerides, and low density lipoprotein were found to be 21.7%, 84.8% and 19.6% respectively. The lipid profile of patients on peritoneal dialysis was markedly elevated as compared to that of patients on maintenance hemodialysis (p-value ≤0.05).

Conclusion: Majority of pediatric patients with end stage renal disease had suffered from dyslipidemia especially raised serum triglycerides. Timely identification of abnormal lipid levels and appropriate management is expected to help reduce cardiovascular morbidity and mortality associated with dyslipidemia in these pediatric patients. Moreover, lipid profile of patients on peritoneal dialysis was more deranged than those on hemodialysis.