DIAGNOSTIC ACCURACY OF TYPHIDOT IN PATIENTS OF TYPHOID FEVER

Diagnostic Accuracy of Typhidot

Abstract

Objective: To assess the diagnostic accuracy of Typhidot test in patients with acute febrile illness taking blood
culture as gold standard.
Study Design: Cross-sectional validation study.
Place and Duration of Study: The study was conducted at Combined Military Hospital Kohat, from Mar 2016 to
Oct 2016.
Material and Methods: In this study 211 patients with acute febrile illness were included. All patients had
Typhidot IgM test done along with blood cultures, blood counts, chemistries and relevant diagnostic tests.
Patients were divided into two groups based on blood culture results and both groups were compared in terms
of positivity for Typhidot. Sensitivity, specificity, positive predictive value and negative predictive value were
calculated using SPSS v 20. Chi square was applied to assess the association between Typhidot and blood culture
results.
Results: Out of total 211patients, 49 patients had typhoid fever (culture positive) and 162 had non-typhoidal
illnesses (culture negative). Typhidot IgM was positive in 47 (95.9%) cases of typhoid fever and in 155 (73.5%)
cases of non-typhoidal fevers. The sensitivity of Typhidot for diagnosis of typhoid fever was 95.9% and specificity
was 26.5%.
Conclusion: Our study reveals that Typhidot IgM has high sensitivity for typhoid fever but specificity and
diagnostic accuracy are very low. Nevertheless, a high negative predictive value means it can help rule out the
disease in suspected cases.