COMPARISON OF MISOPROSTOL (PGE1) ANALOGUE WITH DINOPROSTONE (PGE2) FOR INDUCTION OF LABOUR

Abstract

Objective: To compare the results of induction of labour with misoprostol (PGE1 analogue) with dinoprostone (PGE2 analogue) in terms of induction delivery interval, mode of delivery, and the need for oxytocin augmentation.
Setting: Department of Obstetrics and Gynaecology, Combined Military Hospital, Rawalpindi.
Duration of Study: Six months
Study Design: Randomized controlled trial.
Subject and Method: Total 100 subjects were included in this study. These patients were divided in groups-A and B. Group-A was induced with prostin tablet i.e. dinoprostone PGE2 3 mg tablets maximum of 2 doses, 6 hours apart. Group-B induced with prosotec 50 μgm 4 hourly, 4 doses. The subjects were full term pregnant women
who were either primigravida, 2nd or 3rd gravid and had bishop score less than 5.
Results: The patients included in the study were between the ages of 19 to 37 years. The mean age of group-A was 26.72 ± 4.62 years and of group-B was 28.4 ± 4.94 years (p value > 0.05). All the patients in both groups were between 37 to 42 weeks of gestation. The mean gestational age of group-A was 39.74 ± 2.09 weeks and in group-B it was 39.62 ± 1.55 weeks (p > 0.05). Oxytocin augmentation was required in late 1st stage and 2nd stage in group-A in 68% cases but it was required in only 30% cases in group-B cases. The maximum duration of labour was more than 11 hours in 24% cases in group-A but only 6% in group-B.
Conclusion: Misoprostol (PGE1 analogue) is a useful drug for labour induction. There is short induction delivery interval and reduced need for the use of oxytocin augmentation. There are also less failure rates of induction with misoprostol. Rate of instrumental delivery and caesarean section is also less.