MEFLOQUINE � NEUROPSYCHIATRIC SIDE EFFECTS PROFILE

Abstract

Background: Mefloquine is a drug widely used for prophylaxis and treatment of malaria. The current study was aimed at finding out the common neuropsychiatric side effects in Pakistani troops serving abroad on United Nations peace keeping mission in malaria endemic areas and to prescribe alternative therapy in individuals more susceptible to these side effects. Patients and Methods: In a case control study 76 subjects taking mefloquine on weekly basis and reporting sick to the hospital were assessed for neuropsychiatric symptoms and compared with another 50 subjects not on this drug. This study was conducted at Pak-Field Hospital at Siera leone during 2003 to 2004. Results: Sleep disturbances were found in 52.63%, while 60.52% had depressive and other mood related disorders. Anxiety was present in 35.52% whereas 6.57% subjects had psychotic symptoms. Other neurological symptoms like headache and tremors were common. General fatigue was seen in 61.84% of cases. Visual disturbances, delirium and seizure were not significant in our study. Conclusion: Mefloquine therapy in malaria is frequently associated with serious toxic and neurological side effects. An alternative regimen for prophylaxis and treatment is recommended in subjects who have history of mood disorders, paranoia, anxiety and convulsions.