Age Matched Corneal Endothelial Cell Count in Patients with Pseudo Exfoliation Syndrome

Waqas Rahim Butt; Syed Abid Hassan  Naqvi; Fakhar  Humayun; Ammarah Ashraf; Taimoor Ashraf Khan; Hassan Sajjad Rathore

doi:10.51253/pafmj.v75i6.13428

Authors

Waqas Rahim Butt Department of Ophthalmology, Armed Forces Institute of Ophthalmology Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Syed Abid Hassan Naqvi Department of Ophthalmology, Armed Forces Institute of Ophthalmology Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Fakhar Humayun Department of Ophthalmology, Continental Medical College, Lahore Pakistan
Ammarah Ashraf Department of Ophthalmology, Armed Forces Institute of Ophthalmology Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Taimoor Ashraf Khan Department of Ophthalmology, Combined Military Hospital, Peshawar/National University of Medical Sciences (NUMS) Pakistan
Hassan Sajjad Rathore Department of Ophthalmology, Armed Forces Institute of Ophthalmology Rawalpindi/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75i6.13428

Keywords:

Corneal endothelial cell count, Glaucoma, Intraocular pressure, Pseudo exfoliation syndrome, Intraocular pressure, Specular microscopy

Abstract

Objective: To evaluate corneal endothelial cell count (CECC) in patients with Pseudo Exfoliation Syndrome (PEX) and control participants of matched age along with comparing intra ocular pressure (IOP) between the two groups.

Study Design: Comparative Cross Sectional Study.

Place and Duration of Study: Armed Forces Institute of Ophthalmology Rawalpindi, Pakistan from Dec 2022 to May 2023.

Methodology: A total of 70 participants were enrolled for this cross-sectional analysis through two matched sample groups which included 35 individuals with Pseudo exfoliation syndrome (PEX) and 35 control subjects without Pseudo exfoliation syndrome. A statistical evaluation compared corneal endothelial cell count using specular microscopy and IOP measurement (by Goldman applanation tonometry) between study groups.

Results: The PEX group demonstrated reduced mean Corneal endothelial cell count (CECC) measurements at 1768.29±213.53 cells/mm² compared to control group CECC (2245.89±187.70cells/mm²) with p<0.001 statistical significance. The mean IOP of PEX group was19.90±2.40 mmHg and control group was 15.10±1.80 mmHg. The p-value<0.001 of IOP shows that a direct link between PEX and higher IOP The PEX group showed a negative moderate correlation between CECC and patient age (r = -0.57 p=0.747) which demonstrates CECC decreases in advanced age. The IOP and CECC had strong positive correlation (r = 0.966, p<0.001).

Conclusions: Patients with pseudo exfoliation syndrome showed reduced corneal endothelial cell count (CECC) and higher IOP measurements as compared to the age matched control group.

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