EFFECT OF SYNTOCINON ADMINISTRATION ON INTRAOPERATIVE MEAN ARTERIAL PRESSURE (MAP) DURING ELECTIVE CESAREAN DELIVERY

Effect of Syntocinon on Mean Arterial Pressure

Abstract

Objective: The objective of the study is to compare the effect of syntocinon administration on intraoperative mean arterial pressure in elective caesarean delivery.
Study Design: Randomized Comparative Trial. Place And Duration of Study: Department of Anaesthesiology Combined Military Hospital Quetta from Aug 2011 to Sep 2012.
Material and Methods: All full term females fulfilling inclusion criteria underwent elective caesarean delivery in the operation theatre of CMH Quetta as indoor patients, under spinal anaesthesia and aseptic measures. In group A,10 IU syntocinon I/V bolus followed by 40 IU/L of Normal Saline @ 32 drops/min was given immediately after baby delivery. In group B, 2.5 IU syntocinon I/V bolus followed by 15 IU/L of Normal Saline @ 32 drops/min was given immediately after baby delivery.These women had their intra-operative mean arterial pressure(MAP) recorded at the time of bolus, then after 2min, 5min, 10 min and 15 min. Intra-operative MAP readings were compared among the two groups.
Results: MAP was significantly higher (p-value =0.001) when low dose Syntocinon (2.5 IU syntocinon I/V bolus followed by 15 IU/L of Normal Saline at the rate of 32 drops/min) is given immediately after baby delivery without compromising its therapeutic beneficial effect. Conclusion Administration of low dose syntocinon during elective caesarean delivery has the same therapeutic effects but with an added advantage that MAP remains stable.