Analysis of Hormonal and Metabolic Parameters In Hypothyroidism, Subclinical Hypothyroidism and Pcos

Maleeha Iftikhar; Muhammad Naeem Qureshi; Fayyaz  Hassan; Fuad Ahmad Siddiqi; Imran  Khan; Laila  Yaseen

doi:10.51253/pafmj.v75i3.12770

Authors

Maleeha Iftikhar Department of General Medicine, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Muhammad Naeem Qureshi Department of General Medicine, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Fayyaz Hassan Department of General Medicine, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Fuad Ahmad Siddiqi Department of General Medicine, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Imran Khan Department of General Medicine, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Laila Yaseen Department of General Medicine, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75i3.12770

Keywords:

Follicle stimulating hormone, Hypothyroidism, Thyroid stimulating hormone, Sub-clinical hypothyroidism.

Abstract

Objective: To analyze the hormonal and metabolic parameters in subclinical hypothyroidism, hypothyroidism, and Polycystic Ovary Syndrome (PCOS) among women of reproductive age.

Study Design: Cross-sectional study.

Place and Duration of Study: Combined Military Hospital (CMH), Rawalpindi, Pakistan, from Jan 2024 to Dec 2024.

Methodology: Total 114 participants were enrolled and their blood samples analyzed by dividing into three groups: hypothyroidism without PCOS, subclinical hypothyroidism without PCOS, and PCOS. Blood samples were drawn into gel tubes and centrifuged at 3000 RPM for 5 minutes. The serum was then analyzed using chemiluminescence immunoassay to measure hormonal and metabolic parameters of women of reproductive age. A standardized proforma was used to collect data on demographics, clinical history, and biochemical evaluations.

Results: A total of 114 participants were included in this study. A significant difference was observed in serum follicle stimulating hormones (FSH) level across the group (p=0.007). However, all the other parameters showed no significant difference across the groups with p>0.05. For age and Body Mass Index (BMI), a weak negative correlation with thyroid stimulating hormone (TSH) and FSH, respectively was statistically significant while other hormones showed no significant correlation with age and BMI (p>0.05).

Conclusion: TSH level showed statistically significant difference among females with hypothyroidism, sub-clinical hypothyroidism and PCOS while other hormonal parameters showed no statistically significant difference among groups.

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