Analysis of Hormonal and Metabolic Parameters In Hypothyroidism, Subclinical Hypothyroidism and Pcos

Authors

  • Maleeha Iftikhar Department of General Medicine, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Naeem Qureshi Department of General Medicine, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Fayyaz Hassan Department of General Medicine, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Fuad Ahmad Siddiqi Department of General Medicine, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Imran Khan Department of General Medicine, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Laila Yaseen Department of General Medicine, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75i3.12770

Keywords:

Follicle stimulating hormone, Hypothyroidism, Thyroid stimulating hormone, Sub-clinical hypothyroidism.

Abstract

Objective: To analyze the hormonal and metabolic parameters in subclinical hypothyroidism, hypothyroidism, and Polycystic Ovary Syndrome (PCOS) among women of reproductive age.

Study Design: Cross-sectional study.

Place and Duration of Study: Combined Military Hospital (CMH), Rawalpindi, Pakistan, from Jan 2024 to Dec 2024.

Methodology: Total 114 participants were enrolled and their blood samples analyzed by dividing into three groups: hypothyroidism without PCOS, subclinical hypothyroidism without PCOS, and PCOS. Blood samples were drawn into gel tubes and centrifuged at 3000 RPM for 5 minutes. The serum was then analyzed using chemiluminescence immunoassay to measure hormonal and metabolic parameters of women of reproductive age. A standardized proforma was used to collect data on demographics, clinical history, and biochemical evaluations.

Results: A total of 114 participants were included in this study. A significant difference was observed in serum follicle stimulating hormones (FSH) level across the group (p=0.007). However, all the other parameters showed no significant difference across the groups with p>0.05. For age and Body Mass Index (BMI), a weak negative correlation with thyroid stimulating hormone (TSH) and FSH, respectively was statistically significant while other hormones showed no significant correlation with age and BMI (p>0.05).

Conclusion: TSH level showed statistically significant difference among females with hypothyroidism, sub-clinical hypothyroidism and PCOS while other hormonal parameters showed no statistically significant difference among groups.

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References

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Published

30-06-2025

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How to Cite

1.
Iftikhar M, Qureshi MN, Hassan F, Siddiqi FA, Khan I, Yaseen L. Analysis of Hormonal and Metabolic Parameters In Hypothyroidism, Subclinical Hypothyroidism and Pcos. Pak Armed Forces Med J [Internet]. 2025 Jun. 30 [cited 2025 Jul. 7];75(3):588-92. Available from: https://pafmj.org/PAFMJ/article/view/12770