Association of Macrolide Use and Hearing Loss in Young Adults

Nauman Jamil; Maqbool Raza; Kamran Zamurrad Malik; Jehangir Ahmad Afridi; Shahzaib Shaukat; Fariha Shaheen

doi:10.51253/pafmj.v75i6.12405

Authors

Nauman Jamil Department of ENT, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Maqbool Raza Department of ENT, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Kamran Zamurrad Malik Department of ENT, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Jehangir Ahmad Afridi Department of ENT, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Shahzaib Shaukat Department of ENT, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Fariha Shaheen Department of ENT, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75i6.12405

Keywords:

Hearing loss, Macrolide, Penicillin, Sensorineural Hearing Loss

Abstract

Objective: To determine the association of Macrolide, use and hearing loss in young adults.

Study design: Quasi-experimental study.

Place and Duration of Study: ENT Head and Neck Surgery Department Combined Military Hospital, Rawalpindi, Pakistan from May 2023 to Oct 2023.

Methodology: A total of 54 patients fulfilling the selection criteria were enrolled after taking written informed consent and were divided into two Groups of 27 patients each. Group I consisted of patients with history of Macrolide use, Group II with history of Penicillin use. Sensorineural Hearing Loss (SNHL) was assessed in both Groups and findings were statistically analyzed.

Results: The mean age of the patients was 25.27±3.08 years, the mean duration of symptom was 7.33±2.71 days. There were 30(55.6%) males and 24(44.4%) females in the study. SNHL was reported in 6(11.1%) patients. In Group I, 4(14.8%) patients developed SNHL compared to 2(7.4%) patients in Group II. SNHL rate was higher in Macrolide Group.

Conclusion: The frequency of developing SNHL was found twice in patients who received Macrolide compared to Penicillin Group.

Downloads

Download data is not yet available.

References

Davis AC, Hoffman HJ. Hearing loss: rising prevalence and impact. Bull World Health Organ 2019; 97(10): 646.

https://doi:10.2471/BLT.19.224683

2. Michels TC, Duffy MT, Rogers DJ. Hearing loss in adults: differential diagnosis and treatment. Am Fam physician 2019; 100(2): 98-108.

https://doi.org/10.1016/S0924-8579(01)00319-7

3. Van-Beeck Calkoen EA, Engel M, Van-de Kamp J, Yntema H, Goverts S, Mulder M, et al. The etiological evaluation of sensorineural hearing loss in children. Eur J Pediatr 2019; 178: 1195-205.

https://doi.org/10.1007/s00431-019-03379-8

4. Williams J. Evaluation of the safety of macrolides. Int J Antimicrob Agents 2001; 18: 77-81.

https://doi.org/10.1016/S0924-8579(01)00399-5

5. Altenburg J, De-Graaff C, Van-der Werf T, Boersma W. Immunomodulatory effects of macrolide antibiotics–part 2: advantages and disadvantages of long-term, low-dose macrolide therapy. Respiration 2010; 81(1): 75-87.

https://doi.org/10.1159/000320320

6. Li H, Liu D-H, Chen L-L, Zhao Q, Yu Y-Z, Ding J-J, et al. Meta-analysis of the adverse effects of long-term azithromycin use in patients with chronic lung diseases. Antimicrob Agents Chemother 2014; 58(1): 511-517.

https://doi.org/10.1128/aac.02067-13

7. Hansen MP, Scott AM, McCullough A, Thorning S, Aronson JK, Beller EM, et al. Adverse events in people taking macrolide antibiotics versus placebo for any indication. Cochrane Database System Rev 2019; (1): CD011825.

https://doi.org/10.1002/14651858.CD011825.pub2

8. Coulston J, Balaratnam N. Irreversible sensorineural hearing loss due to clarithromycin. Postgrad Med J 2005; 81(951): 58-59.

https://doi.org/10.1136/pgmj.2004.020412

9. Ress BD, Gross EM. Irreversible sensorineural hearing loss as a result of azithromycin ototoxicity: a case report. Ann Otol Rhinol Laryngol 2000; 109(4): 435-437.

https://doi.org/10.1177/000348940010900416

10. Lindeborg MM, Jung DH, Chan DK, Mitnick CD. Prevention and management of hearing loss in patients receiving ototoxic medications. Bull World Health Organ 2022; 100(12): 789.

http://doi:10.2471/BLT.21.286823

11. Naz E, Saqulain G, Mumtaz N, Babur MN. A Hospital based study on sudden sensorineural Hearing Loss: It’s audiological characteristics and prevalence. Pak J Med Sci 2021; 37(4): 1133.

http://doi:10.12669/pjms.37.4.3851

12. Vanoverschelde A, Oosterloo BC, Ly NF, Ikram MA, Goedegebure A, Stricker BH, et al. Macrolide-associated ototoxicity: a cross-sectional and longitudinal study to assess the association of macrolide use with tinnitus and hearing loss. J Antimicrob Chemother 2021; 76(10): 2708-2716.

https://doi.org/10.1093/jac/dkab232

13. Etminan M, Westerberg BD, Kozak FK, Guo MY, Carleton BC. Risk of sensorineural hearing loss with macrolide antibiotics: A nested case‐control study. Laryngoscope 2017; 127(1): 229-232.

https://doi.org/10.1002/lary.26190

14. Dabekaussen KF, Andriotti T, Ye J, Prince AA, Nguyen LL, Feng AY, et al. Association of outpatient oral macrolide use with sensorineural hearing loss in children, adolescents, and young adults. JAMA Otolaryngol Head Neck Surg 2022; 148(9): 820-827. http://doi:10.1001/jamaoto.2022.1293

15. Wong EH, Porter JD, Edwards MR, Johnston SL. The role of macrolides in asthma: current evidence and future directions. Lancet Respirat Med 2014; 2(8): 657-670.

https://doi.org/10.1016/S2213-2600(14)70107-9

16. Askari M, Khezri M, Zoghi G. Introducing a Novel Combination Therapy with Macrolides for the Treatment of Chronic Rhinosinusitis: A Randomized Controlled Trial. Iran J Med Sci 2022; 47(6): 533.

http://doi:10.30476/IJMS.2021.91813.2303

17. Alsowaida YS, Almulhim AS, Oh M, Erstad B, Abraham I. Sensorineural hearing loss with macrolide antibiotics exposure: a meta-analysis of the association. Int J Pharm Pract 2021; 29(1): 21-28. https://doi.org/10.1111/ijpp.12670

18. Lieu JE, Rybak L. Possibility of Macrolides Causing Hearing Loss in Children—What Did You Say? JAMA Otolaryngol Head Neck Surg 2022; 148(9): 827-829.

http://doi:10.1001/jamaoto.2022.1292

19. Heffernan CB, McKeon MG, Molony S, Kawai K, Stiles DJ, Lachenauer CS, et al. Does clarithromycin cause hearing loss? A 12-year review of clarithromycin therapy for nontuberculous mycobacterial lymphadenitis in children. Ann Otol Rhinol Laryngol 2018; 127(10): 687-693.

https://doi.org/10.1177/0003489418788112

20. Rafique A, Dastgir M, Jamalullah M, Maqbool S, Basher S, Rashid M et al. Streptomycin associated hearing loss in patients treated for multidrug resistant tuberculosis. Isra Med J 2012; 4(3): 139-142.