Thyroid Dysfunction Secondary to Endocrine Disruptive Chemicals – A Systematic Review

Ambreen Gul; Sarah Saleem; Faizan Munir; Aashi Ahmed; Anwar Bibi; Sadia Naeem

doi:10.51253/pafmj.v74i4.12181

Authors

Ambreen Gul Department of Biochemistry, HITEC Institute of Medical Sciences Taxila Pakistan
Sarah Saleem Department of Public Health, Al Khidmat Razi Hospital Islamabad Pakistan
Faizan Munir Department of Medical Education, HITEC Institute of Medical Sciences Taxila Pakistan
Aashi Ahmed Department of Community Medicine, HITEC Institute of Medical Sciences Taxila Pakistan
Anwar Bibi Department of Public Health, Al Khidmat Razi Hospital Islamabad Pakistan
Sadia Naeem Department of Community Medicine, Wah Medical College Wah Cantt Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i4.12181

Keywords:

Endocrine Disruptors, systematic Review, thyroid Hormone, thyroid Diseases.

Abstract

Objectives: To assess the epidemiological data and potential connection between different endocrine chemical disruptors and thyroid hormone abnormalities.

Study Design: The 2020 PRISMA standards were followed when conducting the systematic review. Ten research studies were found and examined after an in-depth review of the scientific literature.

Methodology: The systematic review was aimed to gather all pertinent information, including observational studies (prospective or retrospective cohorts) that address the relationship between exposure to endocrine disruptors and thyroid hormone imbalance.

Results: Ten studies were found, and they demonstrated that these substances, especially in adulthood, impact the level of thyroid hormone and the incidence of thyroid nodules.

Conclusions: Endocrine disruptive chemicals can compromise thyroid function by affecting hormone transporters, gene expression, and the hypothalamic-pituitary-thyroid axis.

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