Evaluating the Frequency of Urinary Tract Infections in Neonates with Prolonged Jaundice at Ghurki Trust Teaching Hospital, Lahore, Pakistan
DOI:
https://doi.org/10.51253/pafmj.v75i6.11980Keywords:
Breastfeeding, Jaundice, Neonatal jaundice, Urinary tract infectionAbstract
Objective: To evaluate the frequency of urinary tract infection (UTI) in neonates with prolonged jaundice.
Study Design: Quasi-experimental study.
Place and Duration of Study: Neonatal Unit, Ghurki Trust Teaching Hospital, Lahore Pakistan, from Apr to Oct 2022.
Methodology: The study included 140 newborns having jaundice for >2 weeks. Blood and urine samples were obtained from patients upon admission and urine samples were sent for culture and urinalysis to detect the presence of pyuria, where 10,000 CFUs of a single infectious agent indicated a urinary tract infection. Additional examinations such as kidney function tests, renal ultrasonography, voiding cystourethrography, and renal scintigraphy were conducted on patients who had a positive urine culture for bacteria.
Results: Out of 140 patients, 88(62.86%) were males and 52(37.14%) were females. In 26 out of 140 neonates (18.57%), UTI was present. Out of 26, 12(23.08%) were females and 14(15.91%) were males. UTI positive group had significant serum bilirubin values compared to UTI negative group (p<0.001). The microorganisms that were found in isolation were Proteus mirabilis in 4(15.38%), Klebsiella pneumonia in 6(23.08%), and Escherichia coli in 16(66.67%) patients.
Conclusion: The prevalence of urinary tract infection in neonates presenting with prolonged jaundice is significant and females were noted to be affected more.
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References
1. Funmilayo OR, Ohaeri B, Ojo IO, Babarımısa O. Neonatal jaundice: Its myths and facts. Euro Afro Stud Int J 2022; 4(5):1-3. https://doi.org/10.33545/easij.2022.v04.i05.001
2. Zahed Pasha Y, Alizadeh-Tabari S, Zahed Pasha E, Zamani M. Etiology and therapeutic management of neonatal jaundice in Iran: A systematic review and meta-analysis. World J Pediatr 2020; 16: 480-493. https://doi.org/10.1007/s12519-020-00384-y
3. Hashim W, Alkhaled M, Al-Naji A, Al-Rayahi I. A review on image processing based neonatal jaundice detection techniques. In: 2021 7th International Conference on Contemporary Information Technology and Mathematics (ICCITM). Piscataway, NJ: IEEE; 2021. p.213-218.
4. Osiak W, Wątroba S, Kapka-Skrzypczak L, Kurzepa J. Two faces of heme catabolic pathway in newborns: A potential role of bilirubin and carbon monoxide in neonatal inflammatory diseases. Oxid Med Cell Longev 2020; 2020: 7140496.
https://doi.org/10.1155/2020/7140496
5. Anand P, Gopalakrishnan S, Sachdeva A, Sahoo T, Sivanandan S. Screening, prevention, and management of neonatal hyperbilirubinemia. J Neonatol 2020; 34(3): 153-169.
https://doi.org/10.1055/s-0040-1713664
6. Baz AM, El-Agamy OA, Ibrahim AM. Incidence of urinary tract infection in neonates with significant indirect hyperbilirubinemia of unknown etiology: Case-control study. Ital J Pediatr 2021; 47: 152.
https://doi.org/10.1186/s13052-021-01101-7
7. Boskabadi H, Sezavar M, Zakerihamidi M. Evaluation of neonatal jaundice based on the severity of hyperbilirubinemia. J Clin Neonatol 2020; 9(1): 46-51.
https://doi.org/10.4103/jcn.JCN_110_19
8. Idrees MM, Rasool MF, Imran I, Khalid A, Saeed A, Ahmad T, et al. A cross-sectional study to evaluate antimicrobial susceptibility of uropathogens from South Punjab, Pakistan. Infect Drug Resist 2022; 15: 1845-1855.
https://doi.org/10.2147/IDR.S33930
9. Gharehbaghi MM, Heidatabady S, Ghasempour M, Alizade M. Developmental outcome of severe neonatal indirect hyperbilirubinemia. J Res Clin Med 2021; 9(1): 1.
https://doi.org/10.34172/jrcm.2021.001
10. Al Owaymir AD, Aseeri RM, Albariqi MA, Alalyani MS, Almansaf JA, Albalwi AB, et al. An overview on diagnosis and management of neonatal jaundice. Arch Pharm Pract 2021; 12(2): 99-102.
https://doi.org/10.4103/2229-4708.329925
11. Hansen TW. The epidemiology of neonatal jaundice. Pediatr Med 2021; 5:18.
https://doi.org/10.21037/pm-21-20
12. Chen I, Hsu LS, Yao CS, Chang JT, Wang HP, Fang NW et al. Risk factors for urinary tract infection in infants with unexplained hyperbilirubinemia: A single center case-control study. Front Pediatr 2024; 12: 1332052.
https://doi.org/10.3389/fped.2024.1332052
13. Chou HH, Huang LC, Shen SP, Tsai ML, Chang YC, Lin HC et al. Neonatal jaundice is associated with increased risks of congenital anomalies of the kidney and urinary tract and concomitant urinary tract infection. Sci Rep 2024; 14(1): 9520.
https://doi.org/10.1038/s41598-024-19576-7
14. Ahmed SM, Jan P, Zaman S, Kakar SU, Shah SA, Ayub AM et al. Frequency of urinary tract infection in neonates admitted with indirect hyperbilirubinemia. Pak J Med Health Sci 2022; 16(9): 302. https://doi.org/10.29309/pjmhs/2022.23.09.4597
15. Afolabi TM, Goodlet KJ, Fairman KA. Association of antibiotic treatment duration with recurrence of uncomplicated urinary tract infection in pediatric patients. Ann Pharmacother 2020; 54(8): 757-766. https://doi.org/10.1177/1060028020916634
16. Aygün E, Ertürk EY, Sayman ÖA, Tiryaki FK. Evaluation of etiological, clinical and laboratory findings in infants with prolonged jaundice. GeroScience 2020; 42(6): 2331-2340.
https://doi.org/10.1007/s11357-020-00208-6
17. Lookzadeh MH, Bahrami R, Ekraminasab S. Prevalence of urinary tract infection in Iranian newborns with jaundice: A meta-analysis. World J Peri Neonatol 2021; 4(3): e1105.
https://doi.org/10.18314/WJPN.2021.1105
18. Daniel M, Szymanik-Grzelak H, Sierdziński J, Podsiadły E, Kowalewska-Młot M, Pańczyk-Tomaszewska M et al. Epidemiology and risk factors of UTIs in children: A single-center observation. J Pers Med 2023; 13(1): 138.
https://doi.org/10.3390/jpm13010138
19. Hasan SM, Jain G, Meena J, Punia S. Clinical features of urinary tract infection in neonates with hyperbilirubinemia: A cross-sectional study.
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Copyright (c) 2025 Sara Hassan, Madiha Iqbal, Sobia Shahalam, Shazia Rizwan, Ayesha Rafiq, Rabeya Rehman
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