Comparison of Interferon-Inducible Patient-10 and Chemokine Ligand-2 Expression in COVID-19 Patients

Authors

  • Nayab Khalid Department of Physiology, Islam Medical and Dental College, Sialkot, Pakistan
  • Mehwish Qamar Department of Physiology, Islam Medical and Dental College, Sialkot, Pakistan
  • Sadia Syed Department of Forensic Medicine & Toxicology, Shifa College of Medicine, Islamabad, Pakistan
  • Ibrahim Liaqat Department of Physiology, Islam Medical and Dental College, Sialkot, Pakistan
  • Muhammad Irfan ul Akbar Yousufzai Department of Physiology, Sahara Medical College, Narowal Pakista
  • Summyah Niazi Department of Physiology, Quetta Institute of Medical Sciences, Quetta Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i1.11796

Keywords:

COVID-19, ELISA test, Inflammatory cytokines

Abstract

Objective: To compare interferon-inducible patient-10 and chemokine lisgand-2 expression in COVID-19 Patients.

Study Design: Cross-sectional study.

Place and Duration of Study: University of Lahore Teaching Hospital, Lahore Pakistan, from Dec 2020 to Mar 2021.

Methodology: We assessed the level of cytokines in forty-five COVID-19 patients and compared it with the 45 healthy
individuals. The pro-inflammatory cytokines IP-10 and CCL-2 levels were evaluated in patients and healthy people via ELISA
kits.

Results: The study included ninety (n=90) patients. Our data suggested that the serum levels of IP-10 and CCL-2 were
increased (8.5±1.5 ng/ml and 11.89±4.55 pg/ml) significantly in patients with COVID-19 as compared to healthy Controls
(4±0.5ng/ml and 6.15±1.91 pg/ml). A significant increase was recorded in INR, PT (sec) and APTT (sec) levels in COVID-19
patients. Whereas the platelets count (109/ml) was decreased significantly in COVID-19 patients (220±42) as compared to
healthy individuals (419±69). Significant elevation of D-Dimer (ng/ml) was recorded in patients with COVID-19.

Conclusion: Our data suggested a significantly increased level of IP-10 and CCL-2 in COVID-19-associated patients, which
may be of essential diagnostic and prognostic significance for these biomarkers.

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Published

28-02-2024

How to Cite

Nayab Khalid, Mehwish Qamar, Sadia Syed, Ibrahim Liaqat, Muhammad Irfan ul Akbar Yousufzai, & Summyah Niazi. (2024). Comparison of Interferon-Inducible Patient-10 and Chemokine Ligand-2 Expression in COVID-19 Patients. Pakistan Armed Forces Medical Journal, 74(1), 238–241. https://doi.org/10.51253/pafmj.v74i1.11796

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