Intra-Operative Wound Irrigation with Normal Saline Solution Versus Topical Antibiotics to Avoid Wound Infection


  • Sajjid Khan Department of Surgery, Combined Military Hospital Bahawalnagar/National University of Medical Sciences (NUMS) Pakistan
  • Afzal Saeed Awan Department of Surgery, Combined Military Hospital Attock/National University of Medical Sciences (NUMS) Pakistan
  • Huma Asad Department of Surgery, Combined Military Hospital Bahawalnagar/National University of Medical Sciences (NUMS) Pakistan
  • Raheel Khan Department of Surgery/ Combined Military Hospital Dera Nawab Sahib/National University of Medical Sciences (NUMS) Pakistan, Department of Surgery, Jinnah Dental Hospital Karachi Pakistan
  • Hira Asad Department of Surgery, Combined Military Hospital Bahawalnagar/National University of Medical Sciences (NUMS) Pakistan



Appendectomy, Anti-bacterial agents, Wounds and Injuries, Surgical wound infection, Imipenem, Cilastatin


Objective: To compare intra-operative wound irrigation with normal saline versus irrigation with Imipenem and Cilastatin
solution to develop surgical site infections in open appendectomy wounds.

Study Design: Quasi-experimental study.

Place and Duration of Study: Department of Surgery, Combined Military Hospital, Bahawalnagar Pakistan, from Oct 2015 to Oct 2017.

Methodology: Patients diagnosed with cases of acute appendicitis and planned to undergo open appendectomy were
randomly divided into two equal groups; Group-A and Group-B. Group-A was subjected to intra-operative wound irrigation
with 100 ml saline solution before skin closure. Group-B was irrigated with Imipenem and Cilastatin solution (500 mg diluted
in 10ml of distilled water). Development of post-operative Surgical Site Infection was checked till the 30th Post-Operative Day.

Results: Frequency of post-operative Surgical Side infection was comparatively less in Group-B (2.4%) as compared to GroupA (8%), which was found to be statistically significant (p-value=0.046)

Conclusion: Intra-operative wound irrigation with Imipenem and Cilastatin solution was superior to normal saline irrigation
regarding the development of Surgical Site Infection in cases undergoing open appendectomy.


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How to Cite

Sajjid Khan, Afzal Saeed Awan, Huma Asad, Raheel Khan, & Hira Asad. (2024). Intra-Operative Wound Irrigation with Normal Saline Solution Versus Topical Antibiotics to Avoid Wound Infection. Pakistan Armed Forces Medical Journal, 74(1), 125–128.



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