Does Vitamin E Protect the Male Reproductive System Against the Noise-Induced Stress?

Authors

  • Maria Yousaf Department of Anatomy, Islamic International Medical College, Rawalpindi Pakistan
  • Humaira Ali Department of Anatomy, Swat Medical College, Swat Pakistan
  • Liaqat Ali Department of Anatomy, Swat Medical College, Swat Pakistan
  • Nomana Mahmood Department of Anatomy, Wah medical college, Wah Pakistan
  • Shazia Imran Department of Anatomy, National University of Sciences & Technology (NUST) School of Health Sciences, Islamabad Pakistan
  • Kishwar Naheed Department of Anatomy, Watim Medical and Dental College, Islamabad Pakistan
  • Amna Shoaib Al Nafees Medical College, Islamabad Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i2.11664

Keywords:

Alph-tocopherol, Antioxidant, Infertility, Noise Stress, Testosterone

Abstract

Objective: To investigate how Tocopherols shield testis' histomorphology in adult rats subjected to noise stress.
Study Design: Laboratory based-experimental study.
Place and Duration of Study: National Institute of Health, Islamabad Pakistan, from Sep 2022 to Sep 2023.
Methodology: A total of 90 albino rats, with weights ranging from 250 to 300 grams, were included in the study. Three Groups
were created: Group-A, Control, and Group-B, daily noise exposure (100 dB); Group-C was administered with Alpha Tocopherol 40 IU/kg dissolved in 0.5 ml corn oil and subjected to noise (100 dB) daily. The seminiferous tubules' germinal
epithelium's diameter and height were measured using Hematoxylin and Eosin and Periodic Acid Schiff staining.
Results: The study compared gross, microscopic, and biochemical parameters between the Experimental and Control Groups.
Group A exhibited an average testicular volume of 1.82±0.05 gms, a mean tubular diameter of 253.72±4.46 µm, and a germinal
epithelial height of 56.47±2.31 µm. Group-B's testicular volume was 1.13±0.07 gms, accompanied by a decrease in tubular
diameter to 182.15±5.05 µm and epithelial height to 36.80±2.79 µm and in comparison to Group-B, Group-C exhibited
enhancements in terms of tubular diameter (251.86±2.00 µm, p<0.001) and epithelial height (55.63±2.02 µm, p<0.001), resulting
in a reduced testicular volume (1.181±0.03 gms, p<0.001).
Conclusion: Noise-induced histomorphological changes in the testis lowered sperm maturation in the germinal cells and
significantly reduced testicular volume. Moreover, α-Tocopherol has a protective effect on histomorphological changes caused
by noise stress.

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Published

29-04-2024

How to Cite

1.
Yousaf M, Humaira Ali, Liaqat Ali, Nomana Mahmood, Shazia Imran, Kishwar Naheed, et al. Does Vitamin E Protect the Male Reproductive System Against the Noise-Induced Stress?. Pak Armed Forces Med J [Internet]. 2024 Apr. 29 [cited 2024 May 24];74(2):512-6. Available from: https://pafmj.org/PAFMJ/article/view/11664

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