Comparison of Sevoflurane Plus Dexmedetomidine Infusion and Dexmedetomidine Infusion to Prevent Awareness During Cardiopulmonary Bypass Surgery

Authors

  • Muhammad Adnan Akram Department of Cardiac Anesthesia, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Waqas Alam Department of Cardiac Anesthesia, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Rehan Masroor Department of Cardiac Anesthesia, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Syed Ali Raza Ali Shah Department of Cardiac Anesthesia, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Imran Bashir Malik Department of Cardiac Anesthesia, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Muhammad Ali Memon Department of Cardiac Anesthesia, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74iSUPPL-1.11624

Keywords:

Awareness during general anesthesia, ,Cardiopulmonary bypass, Dexmedetomidine infusion, Sevoflurane

Abstract

Objective: To find out the frequency of intra-operative awareness and to compare the effect of Sevoflurane plus Dexmedetomidine with only Dexmedetomidine infusion in preventing awareness during cardiopulmonary bypass surgery.

Study Design: Quasi-experimental study.

Place and Duration of Study: Adult Cardiac Surgery and Anesthesiology department, Armed Forces Institute of Cardiology/National Institute of Heart Diseases, Rawalpindi Pakistan, from May to Nov 2023.

Methodology: Eighty patients who underwent elective cardiac surgery (valvular and CABG) on Cardiopulmonary Bypass  under general anesthesia irrespective of age and gender were recruited through non-probability consecutive sampling with non-random allocation of study participants. Patients were divided into S Group (Sevoflurane plus Dexmedetomidine Group) and D Group (Dexmedetomidine Group). Modified Brice questionnaire was used to assess awareness after 24 hours of surgery. Chi-square and t-test were applied to compare the study variables among study groups. p <0.05 was considered as statistically significant.

Results: A total of 80 patients, who underwent cardiac surgery were recruited. Out of which 40(50.0%) were included in S group and 40(50.0%) were included in D group. 67(83.7%) were males and 13(16.3%) were females. Mean age of the study participants was 59.98±6.85 years. Comparison of study groups showed that 4(10.0%) patients from group-D and 3(7.50%) patients of group-S experienced awareness during surgery (p=1.00). Mean Cardiopulmonary Bypass time was significantly different among study groups (p=0.02)

Conclusion: Patients in S-group experienced slightly less awareness as compared to the patients in D-group but the difference was not statistically significant concluding the fact that Dexmedetomidine is sufficient to avoid awareness 

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Published

30-05-2024

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Original Articles

How to Cite

1.
Adnan Akram M, Alam W, Masroor R, Raza Ali Shah SA, Bashir Malik I, Ali Memon M. Comparison of Sevoflurane Plus Dexmedetomidine Infusion and Dexmedetomidine Infusion to Prevent Awareness During Cardiopulmonary Bypass Surgery. Pak Armed Forces Med J [Internet]. 2024 May 30 [cited 2024 Jun. 17];74(SUPPL-1):S57-S61. Available from: https://pafmj.org/PAFMJ/article/view/11624