Platelet-Lymphocyte Ratio (PLR) as an Early Predictor of Severity in Acute Biliary Pancreatitis

Muhammad Nafe Bin Tahir; Roshnik Ayub; Hanya  Awaba; Shehzad Ahmed  Abbasi; Muhammad Yousaf  Shah; Muhammad Ans

doi:10.51253/pafmj.v74i6.11485

Authors

Muhammad Nafe Bin Tahir Department of Surgery, Pakistan Air Force Hospital Mushaf, Sargodha Pakistan
Roshnik Ayub Department of Gynae & Obs, Pakistan Institute of Medical Sciences (PIMS), Islamabad Pakistan
Hanya Awaba Department of Surgery, Fauji Foundation Hospital, Rawalpindi Pakistan
Shehzad Ahmed Abbasi Department of Surgery, Pakistan Air Force Hospital Mushaf, Sargodha Pakistan
Muhammad Yousaf Shah Department of Surgery, Combined Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Muhammad Ans Department of Surgery, 130 Medical Battalion (Minimarg), Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i6.11485

Keywords:

Acute Biliary Pancreatitis, Platelet to Lymphocyte Ratio, Sensitivity

Abstract

Objective: To establish diagnostic precision regarding platelet-lymphocyte ratio for prophesying the severity of acute biliary pancreatitis in the early diagnostic phase, taking the Computed Tomography Severity Index as the gold standard.

Study Design: Cross-sectional validation study.

Place and Duration of Study: Pakistan Air Force Hospital Mushaf Base, Sargodha Pakistan, Jan to Dec 2023.

Methodology: Two hundred and twenty-five (n=225) patients diagnosed with acute biliary pancreatitis lying within an age bracket of 18-70 years (male and female) were inculcated. Patients having chronic diseases such as chronic pancreatitis, diabetes mellitus, cardiovascular diseases, end-stage renal and hepatic diseases, and other causes, e.g., Trauma, Endoscopic Retrograde Cholangiopancreatography, (iatrogenic), hypertriglyceridemia, and alcohol, were excluded. All patients were treated for acute pancreatitis. Seventy-two hours after admission, all patients underwent a Computed Tomography scan for Computed Tomography Severity Index.

Results: Platelet-lymphocyte ratio supported the diagnosis of severe acute pancreatitis in 99(44.0%) patients. Computed Tomography Severity Index findings confirmed severe acute pancreatitis in 93(41.33%) cases. In patients having platelet-lymphocyte ratio positive, 83 were TP, and 16 were FP. In 126 platelet-lymphocyte ratio-negative patients, 10 were FN, and 116 were TN (p=0.0001). Overall sensitivity was 89.25%, specificity was 87.88%, Positive and negative predictive values were 83.84% and 92.06%

Conclusion: The diagnostic precision of platelet-lymphocyte ratio in forecasting the extent of acute biliary pancreatitis during the early diagnostic stage is quite high.

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