Relevance of Serum Ferritin Levels with Severity of Dengue Fever and Thrombocytopenia;   A Prospective Study

Ahmar Rashid; Nidda  Yaseen; Fuad Ahmed  Siddiqi; Imran  Khan; Kanaz Ahmed  Siddiqi; Laila  Yaseen

doi:10.51253/pafmj.v75iSUPPL-1.11436

Authors

Ahmar Rashid Department of Medicine, Combined Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Nidda Yaseen Department of Gynae & Obs, Combined Military Hyderabad /National University of Medical Sciences (NUMS) Pakistan
Fuad Ahmed Siddiqi Department of Medicine, Combined Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Imran Khan Department of Medicine, Combined Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Kanaz Ahmed Siddiqi Department of Medicine, Combined Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Laila Yaseen Department of Medicine, Combined Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75iSUPPL-1.11436

Keywords:

Dengue fever, Dengue with warning signs, Dengue without warning signs, Ferritin levels.

Abstract

Objective: To determine the relevance of increasing levels of serum ferritin with the severity of dengue fever and platelet count.

Study Design: Prospective longitudinal study.

Place and Duration of Study: Medicine Department, Combined Military Hospital, Rawalpindi Pakistan, from Jul to Nov 2023.

Methodology: 110 admitted cases of dengue were selected. Serum ferritin levels and platelet count were done on day one and five of the indoor stay. The levels of serum ferritin were then compared with the severity of dengue. According to the WHO, patients without warning signs of dengue were classified as grade A, those with warning signs as grade B, and patients with severe dengue were classified as grade C.

Results: The levels of Serum ferritin rose significantly on the day five. On day one, the median ferritin was 600.0 (812.5–350.0) ng/ml and median ferritin on day 5 was 1100.0 (2000.0–646.50) ng/ml. Our study results showed that serum ferritin level was increased at day 5 with a statistically significant p-value <0.001. Sixty-three (57.3%) had grade A, 31(28.2%) had grade B and 16(14.5%) had grade C dengue. Hyperferritinemia was observed in 47%, 27%, and 16% of grade A, B, and C patients, respectively. Correlation of Serum Ferritin with Platelet count at day one and day five showed that patients had thrombocytopenia with raised serum ferritin level at day five.

Conclusion: The severity of dengue fever is correlated with elevated blood ferritin levels, which is quite relevant.

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