Termination of Pregnancy: Misoprostol Versus Prostaglandin E2


  • Imama Tul Bushra Department of Obstetrics & Gynecology, Fauji Foundation Hospital, Islamabad Pakistan
  • Faiza Ibrar Department of Obstetrics & Gynecology, Fauji Foundation Hospital, Islamabad Pakistan
  • Saima Qamar Department of Obstetrics & Gynaecology, Akhtar Saeed Medical College, Rawalpindi Pakistan
  • Atikka Masud Department of Obstetrics & Gynecology, Fauji Foundation Hospital, Islamabad Pakistan
  • Touseef Fatima Department of Obstetrics & Gynecology, Fauji Foundation Hospital, Islamabad Pakistan
  • Seema Gul Department of Obstetrics & Gynecology, Watim Medical & Dental College, Islamabad Pakistan




Misoprostol, Prostaglandins, Termination of pregnancy


Objective: To compare the efficacy of vaginal Misoprostol and vaginal prostaglandin E2 in termination of pregnancy.

Study Design: Quasi-experimental study.

Place and Duration of Study: Department of Obstetrics & Gynecology, Fauji Foundation Hospital, Islamabad, Pakistan, from
Apr to Oct 2021.

Methodology: After taking informed consent, a total of 80 women between the age of 20-40 years were included in the study
for termination of pregnancy. Molar or ectopic pregnancy, signs of septic abortion, Chronic Liver Disease, and bleeding
disorders were excluded. In group A, a 200µgm tablet of Misoprostol was inserted intravaginal every 6 hours, a total of 4
doses, while in group B patients, a PGE2 3 mg tablet was inserted intravaginal, a total of 4 doses. All patients in both groups
were evaluated after 24 hours, at which efficacy was noted.

Results: The mean age of women in Group-A was 27.18±3.81 years, and in Group-B was 27.18±4.96 years. The mean
gestational age in Group-A was 11.83±3.24 weeks, and in Group-B was 12.20±3.30 weeks. In this study, efficacy (complete
expulsion of the fetus within 24 hours of medication) was seen in 37 (92.50%) women in Group-A (Vaginal Misoprostol) and
29 (72.50%) women in Group-B (Vaginal prostaglandin E2) with a p-value of 0.019.

Conclusion: This study concluded that the efficacy of vaginal Misoprostol is better in termination of pregnancy as compared to
vaginal prostaglandin E2.


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How to Cite

Imama Tul Bushra, Faiza Ibrar, Saima Qamar, Atikka Masud, Touseef Fatima, & Seema Gul. (2023). Termination of Pregnancy: Misoprostol Versus Prostaglandin E2. Pakistan Armed Forces Medical Journal, 73(6), 1800–1803. https://doi.org/10.51253/pafmj.v73i6.11376



Original Articles