Utility of Clinical Risk Index for Babies (CRIB-II) Scoring System in Prediction of Mortality in Premature Babies Admitted at Neonatal Intensive Care Unit, Combined Military Hospital (CMH), Rawalpindi
DOI:
https://doi.org/10.51253/pafmj.v75i6.11200Keywords:
CRIB, Mortality, Neonate, Prediction, Pre-matureAbstract
Objective: To assess the predictive accuracy of the Clinical Risk Index for Babies (CRIB-II) scoring system for mortality in pre-mature babies admitted in neonatal intensive care unit.
Study Design: Quasi-experimental.
Place and Duration of Study: Department of Pediatrics, Combined Military Hospital, Rawalpindi, Pakistan, from Jan to Jun 2023.
Methodology: A total of 280 neonates were assessed for CRIB-II score and predictive mortality. The CRIB-II score was assessed for all participants in the first 30 minutes of admission to NICU which included gender, gestational age, birth weight in grams on an electronic neonatal weight scale and base excess calculated by arterial blood gas analysis in addition to checking rectal temperature. Higher scores were hypothesized to associated with increased mortality.
Results: After analyzing the primary variables, median CRIB-II scores between both groups showed values of 15.00 (IQR=3.50) in Group N versus 8.00 (IQR=2.00) in Group S (p<0.001). ROC (Receiver operative characteristics) and AUC (area under the curve) analysis showed AUC was 0.962 (95% CI=0.933-0.990) with the best suitable cut-off for sensitivity and specificity at CRIB-II score of 7.5 consistent with a 98.8% sensitivity and 72.3% specificity for mortality.
Conclusion: CRIB-II is an effective scoring system for predicting mortality in NICUs for delivery of effective care.
Downloads
References
1. Cao G, Liu J, Liu M. Global, regional, and national incidence and mortality of neonatal preterm birth, 1990-2019. JAMA Pediatr 2022; 176(8): 787-796.
https://doi.org/10.1001/jamapediatrics.2022.1622
2. Lincetto O, Banerjee A. World Prematurity Day: Improving survival and quality of life for millions of babies born preterm around the world. Am J Physiol Lung Cell Mol Physiol 2020; 319(5): L871-L874.
https://doi.org/10.1152/ajplung.00479.2020
3. Armanian AM, Barekatain B, Sohrabi F, Salehimehr N, Mansourian M. The prevalence of complications of prematurity among 1000 newborns in Isfahan, Iran. Adv Biomed Res 2019; 8: 63.
https://doi.org/10.4103/abr.abr_84_18
4. Saleem S, Tikmani SS, Goudar SS, Hwang K, Dhaded S, Guruprasad G, et al. Neonatal mortality among preterm infants admitted to neonatal intensive care units in India and Pakistan: A prospective study. BJOG 2023; 130(11): 1254-1264.
https://doi.org/10.1111/1471-0528.17581
5. Lee H, Park JH, Cho H. Analysis of research on developmentally supportive care for prematurity in neonatal intensive care unit: A scoping review. Child Health Nurs Res 2022; 28(1): 9-20.
https://doi.org/10.4094/chnr.2022.28.1.9
6. Vardhelli V, Murki S, Tandur B, Saha B, Oleti TP, Deshabhotla S, et al. Comparison of CRIB-II with SNAPPE-II for predicting survival and morbidities before hospital discharge in neonates with gestation ≤32 weeks: A prospective multicentric observational study. Eur J Pediatr 2022; 181(7): 2831-2838.
https://doi.org/10.1007/s00431-022-04463-2
7. Adhisivam B. Clinical scores for sick neonates. Indian J Pediatr 2023; 90(4): 324-325.
https://doi.org/10.1007/s12098-022-04308-9
8. Faridpour F, Shirinabadi Farahani A, Rassouli M, Shariat M, Nasiri M, Ashrafzadeh M et al. Clinical risk index for babies (CRIB-II) scoring system in prediction of mortality risk in preterm neonates in the first 24 hour. Evid Based Care 2020; 10(2): 58-63. https://doi.org/10.22038/EBCJ.2020.49219.2349
9. Hanif A, Ashraf T, Pervaiz MK, Guler N. Prevalence and risk factors of preterm birth in Pakistan. J Pak Med Assoc 2020; 70(4): 577-582.
10. Permatasari RD, Novina N, Aziz MA, Gamayani U, Primadi A. Correlation between gestational age estimated using last menstrual period, ultrasonogram, and the New Ballard Score. Perinatology 2024; 24(1): 46-50.
https://doi.org/10.23886/ejki.24.1.46-50
11. van Beek PE, Andriessen P, Onland W, Schuit E. Prognostic models predicting mortality in preterm infants: Systematic review and meta-analysis. Pediatrics 2021; 147(5): e2020020370.
https://doi.org/10.1542/peds.2020-020370
12. Rehman A, Hamid MH. Accuracy of CRIB II score in predicting the neonatal mortality in very preterm babies. Pak J Med Health Sci 2022; 16(3): 564.
13. Stomnaroska O, Danilovski D. The CRIB II (Clinical Risk Index for Babies II) score in prediction of neonatal mortality. Prilozi (Maked Akad Nauk Umet Odd Med Nauki) 2020; 41(2): 63-71.
https://doi.org/10.2478/prilozi-2020-0021
14. Patra K, Karmakar BC. Neonatal mortality and neurodevelopmental outcome of very low birth weight newborns attending a rural tertiary care hospital, predicted by Clinical Risk Index for Babies Score II (CRIBS II). J Evol Med Dent Sci 2019; 8(19): 1521-1528.
https://doi.org/10.14260/jemds/2019/336
15. Najeeb S, Ejaz E, Raza MA, Sarwar S, Gillani S, Afridi RU, et al. Importance of Clinical Risk Index for Babies score for predicting mortality among neonates. J Ayub Med Coll Abbottabad 2020; 32(4): 502-506.
16. Qasim S, Zahid S, Islam A, Anwar M, Siddique S, Rafique A et al. Clinical Risk Index score (CRIB II) as a predictor of neonatal mortality among premature babies. Pak J Med Health Sci 2022; 16(8): 70-. https://doi.org/10.53350/pjmhs2216870
17. Rehman R, Razzaq A, Ahmad AM, Rehman Z, Rehman R, Ateeq S et al. Effectiveness of the Extended Sick Neonatal Score in predicting mortality in a resource-constrained neonatal care unit. Pak Armed Forces Med J 2023; 73(1): 176-180.
https://doi.org/10.51253/pafmj.v73i1.6880
18. Belsti Y, Nigussie ZM, Tsegaye GW. Derivation and validation of a risk score to predict mortality of early neonates at neonatal intensive care unit: The END in NICU score. Int J Gen Med 2021; 14: 8121-8134.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Haider Ali Awan, Shakeel Ahmed Chaudhry, Yusra Zia, Andleeb Tariq, Namrah Fatima Mujeeb, Huma Mir

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.





