Association of Plasma Atherogenic Index (PAI) with arterial stiffness in normotensive versus hypertensive Patients

Qurat Ul Ain; Muhammad  Younas; Muhammad Qaisar Alam  khan; Ayesha  Niaz; Zujaja Hina  Haroon; Muhammad  Anwar

doi:10.51253/pafmj.v75i6.11120

Authors

Qurat Ul Ain Department of Chemical Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan https://orcid.org/0000-0002-0963-1912
Muhammad Younas Department of Chemical Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Muhammad Qaisar Alam khan Department of Chemical Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Ayesha Niaz Department of Radiology, Armed Forces Institute of Cardiology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Zujaja Hina Haroon Department of Chemical Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Muhammad Anwar Department of Chemical Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75i6.11120

Keywords:

Atherogenic Index, Cardiovascular Disease, Pulse Wave Velocity.

Abstract

Objective: To find Association of Plasma Atherogenic Index with Arterial stiffness in normotensive and hypertensive patients.

Study Design: Diagnostic Accuracy Study.

Place and Duration of Study: Armed Forces Institute of Cardiology (AFIC) and Department of Chemical Pathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi Pakistan, from Oct 2022 to May 2023.

Methodology: Hypertensive and normotensive patients with age group of 30-50 years were included in this study. Semi-structured Questionnaire was structured to collect the information regarding demographics, any comorbidity and medication history.

Results: Total 140 subjects were included in current research at AFIC. Altogether, 92(65.7%) male and 48(34.3%) female were participated. Plasma Atherogenic Index (PAI) is derived Index used for current study and it is divided into low risk (0.1), Intermediate risk (0.1-0.24) and high risk (>0.24). Out of all patients 13(9.3%) were in low risk, 38(27.1%) were in intermediate risk and 89(63.6%) were in high risk category. For association between PWV and PAI with blood pressure computed results showed significant association with p-value <0.001 for both PWV and PAI.

Conclusion: There is strong association between PAI and PWV with hypertension. A calculated index of lipid profile can be used as early predictor for arterial stiffness. PAI can be used as an alternative of PWV as an early screening marker for arterial stiffness in all cardiovascular risk factors.

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References

1. Fan B, Zhang T, Li S, Yan Y, Fan L, Bazzano L, et al. Differential roles of life-course cumulative burden of cardiovascular risk factors in arterial stiffness and thickness. Can J Cardiol 2022; 38(8): 1253-62. https://doi.org/10.1016/j.cjca.2022.03.009

2. Ayub M, Ullah K, Masroor I, Butt GU. Predictive factors for increased aortic pulse wave velocity in renal transplant recipients and its relation to graft outcome. Saudi Journal of Kidney Dis Transplant 2015; 26(6): 1130-1134.

https://doi.org/10.4103/1319-2442.168581

3. Li YW, Kao TW, Chang PK, Chen WL, Wu LW. Atherogenic index of plasma as predictors for metabolic syndrome, hypertension and diabetes mellitus in Taiwan citizens: a 9-year longitudinal study. Sci Rep 2021; 11(1): 9900.

4. Huang H, Yu X, Li L, Shi G, Li F, Xiao J, et al . Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study. Lipids Health Dis 2021; 20(1): 1. https://doi.org/10.1161/CIR.0000000000000678

5. Starzak M, Stanek A, Jakubiak GK, Cholewka A, Cieślar G. Arterial stiffness assessment by pulse wave velocity in patients with metabolic syndrome and its components: Is it a useful tool in clinical practice?. Int J Environ Res Public Health 2022; 19(16): 10368. https://doi.org/10.3390/ijerph191610368

6. Jin W, Chowienczyk P, Alastruey J. Estimating pulse wave velocity from the radial pressure wave using machine learning algorithms. Plos One 2021; 16(6): e0245026.

https://doi.org/10.1371/journal.pone.0245026

7. Sang T, Lv N, Dang A, Cheng N, Zhang W. Brachial-ankle pulse wave velocity and prognosis in patients with atherosclerotic cardiovascular disease: a systematic review and meta-analysis. Hyperten Res 2021; 44(9): 1175-1185.

http://doi.org/s41440-021-00678-2

8. Jae SY, Heffernan KS, Kurl S, Kunutsor SK, Laukkanen JA. Association between estimated pulse wave velocity and the risk of stroke in middle-aged men. Int J Stroke 2021; 16(5): 551-555. https://doi.org/10.1177/1747493020963762

9. Vogiatzi G, Lazaros G, Oikonomou E, Kostakis M, Kypritidou Z, Christoforatou E, et al. The impact of drinking water hardness on carotid atherosclerosis and arterial stiffness. Insights from the'Corinthia'study. Hellenic J Cardiol 2023: 10116. https://doi.org/10.1016/j.hjc.2023.04.006

10. Scicali R, Di Pino A, Ferrara V, Rabuazzo AM, Purrello F, Piro S. Effect of PCSK9 inhibitors on pulse wave velocity and monocyte-to-HDL-cholesterol ratio in familial hypercholesterolemia subjects: Results from a single-lipid-unit real-life setting. Acta Diabetol 2021; 58: 949-957.

http://doi.org/s00592-021-01703-z

11. Kim HL. Arterial stiffness and hypertension. Clin Hypertens 2023; 29(1): 31. https://doi.org/10.1186/s40885-023-00258-1

12. Shi Y, Wen M. Sex-specific differences in the effect of the atherogenic index of plasma on prediabetes and diabetes in the NHANES 2011–2018 population. Cardiovasc Diabetol 2023; 22(1): 1-8. https://doi.org/10.1186/s12933-023-01740-8

13. Aminuddin A, Lazim MR, Hamid AA, Hui CK, Mohd Yunus MH, Kumar J, et al. The association between inflammation and pulse wave velocity in dyslipidemia: an evidence-based review. Mediat Inflam 2020: 1186.

https://doi.org/10.1186/s12933-023-01740-8

14. Starzak M, Stanek A, Jakubiak GK, Cholewka A, Cieślar G. Arterial stiffness assessment by pulse wave velocity in patients with metabolic syndrome and its components: Is it a useful tool in clinical practice?. Int J Environ Res Public Health 2022; 19(16): 10368. https://doi.org/10.3390/ijerph191610368

15. Zhou K, Qin Z, Tian J, Cui K, Yan Y, Lyu S. The atherogenic index of plasma: a powerful and reliable predictor for coronary artery disease in patients with type 2 diabetes. Angiology 2021; 72(10): 934-941. https://doi.org/10.1177/00033197211012129

16. Abid H, Abid Z, Abid S. Atherogenic indices in clinical practice and biomedical research: a short review. Baghdad J Biochem Appl Biol Sci 2021; 2: 60-70.

https://doi.org/10.47419/bjbabs.v2i02.52

17. Choudhary MK, Eräranta A, Koskela J, Tikkakoski AJ, Nevalainen PI, Kähönen M, et al. Atherogenic index of plasma is related to arterial stiffness but not to blood pressure in normotensive and never-treated hypertensive subjects. Blood Pressure 2019; 28(3): 157-167.

https://doi.org/10.1080/08037051.2019.1583060

18. Nam JS, Kim MK, Park K, Choi A, Kang S, Ahn CW, et al. The plasma atherogenic index is an independent predictor of arterial stiffness in healthy Koreans. Angiology 2022; 73(6): 514-519. https://doi.org/10.1177/00033197211054242

19. Radić J, Kolak E, Vučković M, Gelemanović A, Đogaš H, BučanNenadić D, et al. Assessment of Hydration, Nutritional Status and Arterial Stiffness in Hypertensive Chronic Kidney Disease Patients. Nutrients 2023; 15(9): 2045.

https://doi.org/10.3390/nu15092045

20. Mustafa A, Zia T, Tasneem S, Kubra KT, Latif M. The Association between Arterial Stiffness and Obesity in Young Adults: A Case Control Study. J Population Therap Clin Pharmacol 2024; 31(1): 215-220.

https://doi.org/10.53555/jptcp.v31i1.3968