Comparison Of Vitamin D, B12 and Folate Levels In Women with and Without Gestational Diabetes Mellitus Reporting to A Tertiary Care Hospital in Lahore

Najeeb ullah Khan; Abdus  Sattar; Mariam  Saeed; Muhammad Zeeshan  Rana; Hina  Anwar

doi:10.51253/pafmj.v75i5.10980

Authors

Najeeb ullah Khan Department of Pathology, Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
Abdus Sattar Department of Pathology, Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
Mariam Saeed Department of Pathology, Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
Muhammad Zeeshan Rana Department of Pathology, Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
Hina Anwar Department of Pathology, Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75i5.10980

Keywords:

Folate, Gestational Diabetes Mellitus, Vitamin B12, Vitamin D

Abstract

Objective: To compare vitamin D, B12 and Folate levels in women with and without gestational diabetes mellitus (GDM) and to find any association of these markers with GDM.

Study Design: Comparative Cross-sectional study.

Place and Duration of Study: Pathology Department, Combined Military Hospital (CMH), Lahore Pakistan, from Feb 2023 to Aug 2023.

Methodology: Vitamin B12, vitamin D and folate levels were assessed in two groups: those with normal glucose tolerance (Group-A, n=108), and women diagnosed with GDM (Group-B, n=54). The comparison of vitamin levels was conducted using the Mann Whitney U test. The association between these vitamins and fasting blood glucose level was explored using multiple linear regression.

Results: Females with GDM had lower levels of vitamin B12 (156 pmol/L vs 198 pmol/L), vitamin D (48 nmol/L vs 59 nmol/L) and higher levels of serum folate (40 nmol/L vs 29 nmol/L). The difference in serum values of folate (p=0.003), vitamin B12 (p=0.001) and vitamin D (p=0.002) between the GDM and NGT groups was statistically significant. Vitamin B12 deficiency was observed in 23.4% (n=38) of the study population. About 86% females (n=140) either had deficient or insufficient vitamin D levels. Folate excess was recorded in 25% (n=40) of the participants.

Conclusion: Women with Gestational Diabetes Mellitus had comparatively higher serum folate levels and lower levels of vitamins B12 and D as compared to women without GDM, and there is an association of these vitamins with GDM.

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