Prophylactic Administration of Low Dose  Midazolam and Ketamine in Prevention of Profound Hypotension in Severely Anxious Females Undergoing Cesarean Section

Kaukab  Majeed; Chaudhry Amjad  Ali; Fatima Sharif  Khan; Akhtar  Hussain; Kaswar Sajjad Ansari; Sajjad  Qureshi

doi:10.51253/pafmj.v75i1.10888

Authors

Kaukab Majeed Department of Anesthesiology, Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Chaudhry Amjad Ali Department of Anesthesiology, Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Fatima Sharif Khan Department of Obs & Gynae, Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Akhtar Hussain Department of Anesthesiology, Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Kaswar Sajjad Ansari Department of Medicine, Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Sajjad Qureshi Department of Anesthesiology, Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75i1.10888

Keywords:

Anxiety, Ketamine, Midazolam, Pregnancy, Visual Analogue Score (VAS).

Abstract

Objective: To compare the efficacy of a combination of Midazolam and Ketamine in providing anxiolysis to prevent profound hypotension in severely anxious patients undergoing cesarean section.

Study Design: Quasi-Experimental Study

Place and Duration of Study: Combined Military Hospital Quetta, Pakistan from Mar to Apr 2023.

Methodology: The study population included female patients of reproductive age group undergoing lower segment cesarean section under spinal anesthesia. A total of 100 patients were recruited. The study sample was divided into two sets. The first set of patients was labeled Group-A and second was labeled as Group-B. Visual Analogue Scale for Anxiety (VAS‐A) was used to assess the anxiety in all patients. Group-A received premedication (Ketamine and Midazolam) and Group-B patients didn’t receive the premedication and they were only given Verbal Reassurance. The primary outcome was frequency of hypotension in patients of moderate-severe anxiety.

Results: The frequency of the adverse outcomes was higher in Group-B as compared to Group-A. The frequency of tachycardia was 1(2%) versus 17(34%), hypotension was 1(2%) versus 17(34%), nausea/vomiting was 2(4%) versus 9(18%), shivering was 2(4%) versus 9(18%), and Diaphoresis was 2(4%) versus 5(10%) in Group-A versus Group-B respectively. Conclusion: The combination of low dose Midazolam (0.03mg/kg) and Ketamine (0.2mg/kg) prevents anxiety related hypotension in gravid female undergoing cesarean section under spinal anesthesia.

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