Obesity and Acanthosis Nigricans as the Clinical Markers of Insulin Resistance and Type-2 Diabetes Mellitus in Young Patients; A Case Report of Two Cases
DOI:
https://doi.org/10.51253/pafmj.v74i1.10865Keywords:
Child, Diabetes mellitus, Type 2, Anti-GAD65 autoantibody, Islet cell antibodies, Hypothyroidism, Cushing syndrome, Diabetes mellitus, Insulin-resistant, Acanthosis NigricansAbstract
Two young girls, aged 11 and 12 years, presented with obesity and Acanthosis Nigricans. They were found to have severe
insulin resistance and type-2 diabetes mellitus. Anti-glutamic acid decarboxylase and anti-islet cell antibodies were negative.
Tests for hypothyroidism and Cushing’s syndrome were negative. They were managed with lifestyle modification and
metformin.
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