Comparison of Hemodynamic Stability in Patients with Intrathecal 0.75% Hyperbaric Bupivacaine Alone and with Pethidine
DOI:
https://doi.org/10.51253/pafmj.v75i3.10848Keywords:
Bupivacaine, Hemodynamic, Hypotension, Pethidine, Spinal Anesthesia.Abstract
Objective: To find out whether hemodynamic stability is noted in patients with intrathecal 0.75% hyperbaric bupivacaine alone and compared with pethidine.
Study Design: Quasi-experimental study.
Place and Duration of Study: Department of Anesthesiology, Combined Military Hospital, Multan. Pakistan, from Jan to Dec 2023.
Methodology: Pregnant women (n=78) with gravidity ≤2, undergoing elective lower segment cesarean section (LSCS) surgery were selected. They were divided into two equal groups: Group A and B, with n=40 in each. Group A received 10mg of 0.75% bupivacaine whereas Group B were injected with 7.5mg of 0.75% bupivacaine plus 25mg of pethidine. Comparative decrease in blood pressure in terms of Mean Arterial Pressure (MAP), incidence of hypotension, bradycardia, nausea and post-spinal shivering were noted.
Results: Mean Arterial Pressure (MAP) decreased in both groups at 2.5-minute post-intrathecal injection, but this decline was more prominent in Group A (64.56±6.10 mmhg versus 73.33±9.37 mmhg) than for Group B (p 0.001). At the 10th minute, decline in MAP was less but the difference between the two groups remained statistically significant. Similarly, frequency of bradycardia and post-op shivering remained on the lower side in Group B while a major difference was seen in the frequency of hypotension between both the groups.
Conclusion: Addition of pethidine to bupivacaine, for intrathecal, use keeps the hemodynamic profile of the patients relatively more stable and avoids adverse events.
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Copyright (c) 2025 Muhammad Ammar Amjad, Muhammad Ali, Muhammad Saeed, Abdullah ., Muhammad Ali, Syed Majid Waseem, Abdul Khalique
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